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首页> 外文期刊>Cytokine >The significance of persistent newly developed autoantibodies in JIA patients under long-term anti-TNF treatment.
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The significance of persistent newly developed autoantibodies in JIA patients under long-term anti-TNF treatment.

机译：在长期抗TNF治疗下，JIA患者体内持续存在的新型自身抗体的重要性。

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OBJECTIVE: To study the significance of persistent (12 months) new autoantibodies, in Juvenile Idiopathic Arthritis (JIA) patients treated with either Infliximab (INFL) or Etanercept (ET) for 2 years. PATIENTS-METHODS: 26 children under INFL (n=12) or ET (n=14) were prospectively studied. A large panel of autoantibodies was tested using indirect immunofluorescence (ANA, anti-dsDNA, anti-ENA, SMA, LKM, AMA, PCA, anti-R1, ATA), ELISA (ANA, anti-ENA, anti-cardiolipin, ANCA), immunoblotting assay (anti-ENA: anti-Ro, anti-La, anti-Sm, anti-URNP, anti-Jo, anti-Scl70, anti-centromere, anti-ribosomal and anti-histone) and rate nephelometry (RF). RESULTS: Apart from the positive patients for ANA (13/26) and RF (2/26) prior to anti-TNF treatment, 6/26 patients (23%) developed new autoantibodies (SMA, anti-R1, ATA) which persisted for 12-50 months. None developed antibodies to nuclear antigens. In only one case, ATA was associated with the development of Hashimoto's thyroiditis. CONCLUSIONS: These findings indicate that in JIA patients in contrast to adult RA patients, development of new autoantibodies to various nuclear antigens is rare. Other non relevant to rheumatic diseases autoantibodies, may appear and persist for >12 months, but very rarely they may be related to clinical entities, especially in the presence of a positive family history of autoimmunity.
机译：目的：研究用英夫利昔单抗（INFL）或依那西普（ET）治疗2年的青少年特发性关节炎（JIA）患者中持续（12个月）新自身抗体的意义。患者方法：前瞻性研究了26名INFL（n = 12）或ET（n = 14）的儿童。使用间接免疫荧光（ANA，抗dsDNA，抗ENA，SMA，LKM，AMA，PCA，抗R1，ATA），ELISA（ANA，抗ENA，抗心磷脂，ANCA）测试了一大批自身抗体，免疫印迹试验（抗ENA：抗Ro，抗La，抗Sm，抗URNP，抗Jo，抗Scl70，抗着丝粒，抗核糖体和抗组蛋白）和比浊法（RF） 。结果：除抗TNF治疗前ANA（13/26）和RF（2/26）阳性的患者外，6/26患者（23％）产生了新的自身抗体（SMA，抗R1，ATA），并持续存在持续12-50个月。没有人开发出针对核抗原的抗体。仅在一种情况下，ATA与桥本甲状腺炎的发展有关。结论：这些发现表明，与成年RA患者相比，在JIA患者中，很少有针对各种核抗原的新的自身抗体的开发。其他与风湿性疾病无关的自身抗体可能会出现并持续> 12个月，但很少与临床实体相关，尤其是在存在自身免疫阳性家族史的情况下。

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