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首页> 外文期刊>Cytokine >Interleukin-8 -251 A/T gene polymorphism and gastric cancer susceptibility: a meta-analysis of epidemiological studies.
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Interleukin-8 -251 A/T gene polymorphism and gastric cancer susceptibility: a meta-analysis of epidemiological studies.

机译：白细胞介素-8 -251 A / T基因多态性与胃癌易感性：流行病学研究的荟萃分析。

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Previous studies suggested the relationship between interleukin (IL)-8 -251 A/T gene polymorphism and risk of gastric cancer (GC). However, the currently available results were not consistent. The present study aimed to quantitatively analyse this association using a meta-analysis. Published literature from PubMed, EMBASE and CNKI (China Knowledge Resource Integrated Database) were retrieved. Twelve case-control studies with 3012 cases of GC and 3893 controls were included. Overall, IL-8 -251 A/T polymorphism was not associated with the risk of GC. However, when stratified for ethnicity/country, the results showed that A allele carriers had an increased risk of GC while T allele carriers had a decreased risk of GC in Korean people. When stratified for Helicobacter pylori infection, the results showed that A allele carriers with H. pylori infection had an increased risk of GC while T allele carriers with or without H. pylori infection had a decreased risk of GC. When stratified for tumor location and histological type (Lauren's classification), A allele carriers had an increased risk of intestinal- and diffuse-type of GC and non-cardia cancer, while T allele carriers had a decreased risk of intestinal- and diffuse-type of GC and non-cardia cancer. These results suggest that overall IL-8 -251 A/T gene polymorphism is not associated with the risk of GC and the association may be varied according to histological type, tumor location, H. pylori infection and ethnicity/country. More well-designed studies based on larger population are needed to confirm our results and further evaluate the association between IL-8 -251 A/T gene polymorphism and gastric cancer.
机译：先前的研究提示白介素（IL）-8 -251 A / T基因多态性与胃癌（GC）风险之间的关系。但是，当前可获得的结果不一致。本研究旨在使用荟萃分析定量分析这种关联。检索来自PubMed，EMBASE和CNKI（中国知识资源集成数据库）的已出版文献。包括十二个病例对照研究，其中包括3012例GC和3893例对照。总体而言，IL-8 -251 A / T多态性与GC风险无关。但是，按种族/国家/地区进行分层时，结果显示，在韩国人中，A等位基因携带者的GC风险较高，而T等位基因携带者的GC风险较低。当对幽门螺杆菌感染进行分层时，结果表明，具有幽门螺杆菌感染的A等位基因携带者具有增加的GC风险，而具有或没有幽门螺杆菌感染的T等位基因携带者具有降低的GC风险。当按肿瘤位置和组织学类型（Lauren's分类）分层时，A等位基因携带者发生GC和非-门癌的肠道和弥漫性类型的风险增加，而T等位基因携带者出现肠和弥漫性类型的风险降低GC和非心脏病的发生。这些结果表明，总的IL-8 -251 A / T基因多态性与GC的风险无关，并且该关联可能根据组织学类型，肿瘤位置，幽门螺杆菌感染和种族/国家而异。需要基于大量人群的更多设计良好的研究来证实我们的结果，并进一步评估IL-8 -251 A / T基因多态性与胃癌之间的关联。

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