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首页> 外文期刊>Cytokine >Role of serum concentration of VEGFR1 and TIMP2 on clinical outcome in primary cervical cancer: Results of a companion protocol of the randomized, NOGGO-AGO phase III adjuvant trial of simultaneous cisplatin-based radiochemotherapy vs. carboplatin and paclitaxel containing sequential radiotherapy
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Role of serum concentration of VEGFR1 and TIMP2 on clinical outcome in primary cervical cancer: Results of a companion protocol of the randomized, NOGGO-AGO phase III adjuvant trial of simultaneous cisplatin-based radiochemotherapy vs. carboplatin and paclitaxel containing sequential radiotherapy

机译：VEGFR1和TIMP2的血清浓度对原发性宫颈癌临床疗效的作用：基于顺铂同时放化疗与含顺铂和顺铂的紫杉醇同时化疗的随机，NOGGO-AGO III期辅助试验的伴随方案的结果

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Objective: Aim of the present study was to analyze the expression-profile of IGF1, IGFBP3, sICAM1, sVCAM1, MMP2, MMP9, TIMP2, VEGFA, VEGFD, VEGFC and VEGFR1 in patients with high-risk FIGO-stage Ib-IIb cervical cancer. Methods: Serum from 68 cervical cancer patients treated within a phase-III-trial with either simultaneous cisplatin radiochemotherapy or sequential systemic carboplatin and paclitaxel followed by percutaneous irradiation was analyzed by ELISA. Both target expression and correlation with important clinicopathological factors were analyzed following standard statistic procedures. Results: All 68 patients underwent a primary radical hysterectomy with pelvic and/or paraaortic lymphadenectomy. 85.3% of the extirpated tumors had clear surgical margins (R0). Increased levels of VEGFR1, TIMP2 and MMP2 were significantly associated with positive surgical margins (p= 0.004, p= 0.018 and p= 0.004, respectively). High concentration of MMP2 and TIMP2 correlated additionally with an advanced age at time of diagnosis (p= 0.001 and p= 0.007, respectively). For the cut-off value of 100. pg/ml, an increased VEGFR1 was significantly associated with poor overall (OS) and progression-free (PFS) survival (p= 0.017 and p= 0.015, respectively). A TIMP2 concentration of lower than 90. ng/ml was significantly associated with poorer OS and PFS (p= 0.009 and p= 0.043, respectively). In the multivariate analysis, TIMP2 expression in serum was the only independent prognostic factor for OS (p= 0.032, HR = 6.51, 95% CI = 1.17-36.01). Conclusions: Expression-profile of specific biomarkers associated with tumor invasion, cell migration and angiogenesis seems to be of prognostic value for both OS and PFS in patients undergoing surgery due to primary cervical cancer. Further analyses are warranted to allow an implementation of such markers into clinical practice. ? 2013 Elsevier Ltd.
机译：目的：本研究旨在分析IGF1，IGFBP3，sICAM1，sVCAM1，MMP2，MMP9，TIMP2，VEGFA，VEGFD，VEGFC和VEGFR1在高危FIGO期Ib-IIb宫颈癌患者中的表达情况。方法：采用ELISA法对68例宫颈癌患者的III期试验中同时进行顺铂放化疗或序贯全身性卡铂和紫杉醇治疗，然后经皮照射进行分析。按照标准的统计程序分析靶标的表达以及与重要临床病理因素的相关性。结果：所有68例患者均接受了根治性子宫全切除术，并进行了盆腔和/或主动脉旁淋巴结清扫术。 85.3％的切除肿瘤具有明确的手术切缘（R0）。 VEGFR1，TIMP2和MMP2水平的升高与手术切缘阳性显着相关（分别为p = 0.004，p = 0.018和p = 0.004）。 MMP2和TIMP2的高浓度还与诊断时的高龄有关（分别为p = 0.001和p = 0.007）。对于100.pg/ml的临界值，增加的VEGFR1与较差的总体（OS）和无进展（PFS）存活率显着相关（分别为p = 0.017和p = 0.015）。低于90. ng / ml的TIMP2浓度与较差的OS和PFS显着相关（分别为p = 0.009和p = 0.043）。在多变量分析中，血清TIMP2表达是OS的唯一独立预后因素（p = 0.032，HR = 6.51，95％CI = 1.17-36.01）。结论：与原发性子宫颈癌手术患者的OS和PFS相比，与肿瘤浸润，细胞迁移和血管生成相关的特定生物标志物的表达谱似乎具有预后价值。保证进行进一步分析以允许将此类标记物应用于临床实践。 ？ 2013爱思唯尔有限公司

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