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首页> 外文期刊>Cytokine >Impact of insulin-like growth factor 2, insulin-like growth factor receptor 2, insulin receptor substrate 2 genes polymorphisms on susceptibility and clinicopathological features of hepatocellular carcinoma
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Impact of insulin-like growth factor 2, insulin-like growth factor receptor 2, insulin receptor substrate 2 genes polymorphisms on susceptibility and clinicopathological features of hepatocellular carcinoma

机译：胰岛素样生长因子2，胰岛素样生长因子受体2，胰岛素受体底物2基因多态性对肝细胞癌易感性和临床病理特征的影响

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Background: Hepatocellular carcinoma (HCC) is one of the major causes of cancer-related death worldwide. Insulin-like growth factor-2 (IGF-2) is an important autocrine and paracrine growth factor which may induce cell proliferation and inhibit cell apoptosis leading to the transformation of normal cells into malignant cells. This study aimed to evaluate the possible roles of IGF-2, insulin-like growth factor-2 receptor (IGF-2R), and insulin receptor substrate (IRS)-2 genes polymorphisms in susceptibility and clinicopathological features of HCC in Egyptian population. Materials and methods: Four hundred and twenty-six HCC patients and 334 controls were enrolled in the study. Polymorphisms of IGF-2+3580, IGF-2+3123, IGF-2R 1619, and IRS-2 1057 gene were detected using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). Serum IGF-2 were determined using ELISA. Results: Serum IGF-2 levels were significantly lower in HCC patients than in healthy controls. IGF-2+3580 AA genotype, IGF-2+3123 GG genotype or G allele, IRS-2 1057 DD genotype and D allele were significantly associated with HCC risk. The combination of IGF-2+3580 AA homozygosity and IGF-2R 1619 GG homozygosity presented a significant protective effect against HCC (OR. = 0.16,95% CI. = 0. 08-0.34, P= 0. 005). Serum IGF-2 concentrations were significantly increased in HCC patients with the IGF-2+3580 AA genotype. We also observed that increased alpha-fetoprotein (AFP), Child-Pugh grade, tumor size, and number of malignant lesions were accompanied by a significant increase of serum IGF-2 mean values of in HCC patients. Conclusion: IGF-2, IGF-2R, and IRS-2 genes polymorphisms and their combinations are associated with risk of HCC.
机译：背景：肝细胞癌（HCC）是全球范围内与癌症相关的死亡的主要原因之一。胰岛素样生长因子2（IGF-2）是重要的自分泌和旁分泌生长因子，可诱导细胞增殖并抑制细胞凋亡，从而导致正常细胞转化为恶性细胞。这项研究旨在评估IGF-2，胰岛素样生长因子2受体（IGF-2R）和胰岛素受体底物（IRS）-2基因多态性在埃及人群HCC易感性和临床病理特征中的可能作用。材料和方法：426名HCC患者和334名对照参加了研究。使用聚合酶链反应限制片段长度多态性（PCR-RFLP）检测了IGF-2 + 3580，IGF-2 + 3123，IGF-2R 1619和IRS-2 1057基因的多态性。使用ELISA测定血清IGF-2。结果：HCC患者的血清IGF-2水平显着低于健康对照组。 IGF-2 + 3580 AA基因型，IGF-2 + 3123 GG基因型或G等位基因，IRS-2 1057 DD基因型和D等位基因与HCC风险显着相关。 IGF-2 + 3580 AA纯合子和IGF-2R 1619 GG纯合子的组合显示出对HCC的显着保护作用（OR。= 0.16,95％CI。0. 08-0.34，P = 0.005）。 IGF-2 + 3580 AA基因型的HCC患者血清IGF-2浓度显着增加。我们还观察到，肝癌患者中甲胎蛋白（AFP），Child-Pugh分级，肿瘤大小和恶性病变数目增加伴随着血清IGF-2平均值的显着增加。结论：IGF-2，IGF-2R和IRS-2基因多态性及其组合与肝癌风险有关。

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