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Lipopolysaccharide (LPS) exposure differently affects allergic asthma exacerbations and its amelioration by intranasal curcumin in mice

机译:脂多糖(LPS)暴露不同程度地影响过敏性哮喘急性发作及其通过鼻内姜黄素的缓解

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Aim: Lipopolysaccharide (LPS) is ubiquitous in the environment and can therefore, exacerbate allergic responses. Studies have suggested immunoregulatory effects of LPS according to route, dose and stage of exposure. Present study has examined whether dose and stage of LPS exposure (during sensitization and challenge with OVA) exacerbates airway inflammations, antigen specific-IgE level, histamine release, Th1/Th2 cytokine response. Further, anti-asthmatic potential of curcumin, through intranasal route has been evaluated for the first time in LPS induced airway inflammation in an ovalbumin (OVA)-challenged mouse asthma model.
机译:目的:脂多糖(LPS)在环境中无处不在,因此会加剧过敏反应。研究表明,根据暴露的途径,剂量和阶段,LPS具有免疫调节作用。目前的研究已经检查了LPS暴露的剂量和阶段(致敏和用OVA攻击期间)是否会加剧气道炎症,抗原特异性IgE水平,组胺释放,Th1 / Th2细胞因子反应。此外,在卵白蛋白(OVA)挑战的小鼠哮喘模型中,首次通过鼻内途径评估姜黄素的抗哮喘潜力。

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