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首页> 外文期刊>Cytokine >Effect of ulcerative colitis activity on plasma concentration of transforming growth factor beta1.
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Effect of ulcerative colitis activity on plasma concentration of transforming growth factor beta1.

机译：溃疡性结肠炎活动对转化生长因子beta1血浆浓度的影响。

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摘要

Enhanced expression of transforming growth factor-beta1 (TGF-beta1) demonstrated in human colonic mucosa of patients with ulcerative colitis (UC), indicates its possible significance in the pathogenesis of this disease. The aim of this study was to evaluate plasma TGF-beta1 concentration in patients with different degrees of colonic mucosal injury, as a possible indicator of ulcerative colitis activity. TGF-beta1 concentration was measured with an enzyme immunoassay (EIA) in plasma of 45 patients with endoscopically confirmed UC. Values observed in UC patients (40.5+/-15.9 ng/ml) were significantly higher than in healthy people (18.3+/-11.6 ng/ml) and higher than in patients with irritable colon syndrome (ICS), (20.5+/-13.6 ng/ml). The highest plasma TGF-beta1 (58.6+/-112.1 ng/ml) was in patients with the severe UC course. TGF-beta1 level analysed in all UC patients revealed significant positive correlation with scored degree of mucosal injury (r=0.396;P<0.01). Among other possible laboratory markers of the disease activity, only C-reactive protein concentration demonstrated significant correlation. Enhanced production of TGF-beta1 can be related to inflammation activity. Measurement of plasma TGF-beta1 may be considered as a biomarker of the disease activity. Copyright 2001 Academic Press.
机译：在溃疡性结肠炎（UC）患者的人结肠粘膜中显示出转化生长因子-beta1（TGF-beta1）的增强表达，表明其在该疾病的发病机理中可能具有重要意义。这项研究的目的是评估不同程度的结肠粘膜损伤患者的血浆TGF-β1浓度，作为溃疡性结肠炎活动的可能指标。内镜确诊的UC患者中45例患者血浆中TGF-β1的浓度采用酶联免疫法（EIA）进行了测定。在UC患者中观察到的值（40.5 +/- 15.9 ng / ml）显着高于健康人（18.3 +/- 11.6 ng / ml），也高于患有肠易激综合症（ICS）的患者（20.5 +/- 13.6 ng / ml）。患有严重UC病程的患者血浆TGF-β1最高（58.6 +/- 112.1 ng / ml）。在所有UC患者中分析的TGF-β1水平显示出与粘膜损伤评分的显着正相关（r = 0.396; P <0.01）。在疾病活动的其他可能的实验室标记中，只有C反应蛋白浓度显示出显着的相关性。 TGF-beta1的生产增加可能与炎症活动有关。血浆TGF-beta1的测量可以被认为是疾病活动的生物标志。版权所有2001，学术出版社。

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