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首页> 外文期刊>Cytokine >Peri- and post-operative course of cytokines and the metabolic activity of neutrophils in human liver transplantation.
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Peri- and post-operative course of cytokines and the metabolic activity of neutrophils in human liver transplantation.

机译:人肝移植中细胞因子的围手术期和术后过程以及中性粒细胞的代谢活性。

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摘要

Peri- and post-operative (up to day 7 after surgery) neutrophil chemiluminescence and the plasma concentrations of interleukin 6 (IL-6), IL-8, IL-10 and tumour necrosis factor alpha (TNF-alpha) were evaluated in the blood of patients undergoing liver transplantation. IL-6, IL-8 and IL-10 levels increased during early reperfusion and then returned to normal mostly within the first post-operative day. TNF-alpha was increased during the whole period observed. Spontaneous as well as activated neutrophil chemiluminescence was depressed in early reperfusion and remained low during the whole period followed. Samples collected during early reperfusion provided positive correlation for IL-6 vs IL-8 as well as for IL-6 and IL-8 vs chemiluminescence. The data were also evaluated with respect to the outcome of transplantation. Since IL-8, IL-10 and TNF-alpha levels increased significantly during the first post-operative week, mainly in a group of patients who developed serious complications within the first month after surgery, we proved a connection between peri- and early post-operative induction of cytokine release and the outcome of liver allograft transplantation. Copyright 2001 Academic Press.
机译:在手术前后(手术后直至第7天)评估中性粒细胞的化学发光和白细胞介素6(IL-6),IL-8,IL-10和肿瘤坏死因子α(TNF-alpha)的血浆浓度。肝移植患者的血液。 IL-6,IL-8和IL-10的水平在早期再灌注期间升高,然后在术后第一天大部分时间恢复正常。在整个观察期间,TNF-α升高。在早期的再灌注过程中,自发性和激活性中性粒细胞化学发光被抑制,并在随后的整个过程中保持较低水平。在早期再灌注期间收集的样品对IL-6与IL-8以及IL-6和IL-8与化学发光呈正相关。还就移植结果评估了数据。由于IL-8,IL-10和TNF-α的水平在术后第一周显着增加,主要是在手术后第一个月内出现严重并发症的一组患者中,我们证明了围手术期与术后早期之间存在联系诱导细胞因子释放和异体肝移植的结果。版权所有2001,学术出版社。

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