• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biochimica et biophysica acta. Biomembranes >Alterations to plasma membrane lipid contents affect the biophysical properties of erythrocytes from individuals with hypertension
【24h】

Alterations to plasma membrane lipid contents affect the biophysical properties of erythrocytes from individuals with hypertension

机译：对血浆膜脂质含量的改变影响具有高血压的个体的红细胞的生物物理性质

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Genetic and environmental factors may contribute to high blood pressure, which is termed essential hypertension. Hypertension is a major independent risk factor for cardiovascular disease, stroke and renal failure; thus, elucidation of the etiopathology of hypertension merits further research. We recently reported that the platelets and neutrophils of patients with hypertension exhibit altered biophysical characteristics. In the present study, we assessed whether the major structural elements of erythrocyte plasma membranes are altered in individuals with hypertension. We compared the phospholipid (phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, sphingosine) and cholesterol contents of erythrocytes from individuals with hypertension (HTN) and healthy individuals (HI) using LC/MS-MS. HTN erythrocytes contained higher phosphatidylcholine, phosphatidylethanolamine and phosphatidylserine contents and a lower cholesterol content than HI erythrocytes. Furthermore, atomic force microscopy revealed important morphological changes in HTN erythrocytes, which reflected the increased membrane fragility and fluidity and higher levels of oxidative stress observed in HTN erythrocytes using spectrophotofluorometry, flow cytometry and spectrometry. This study reveals that alterations to the lipid contents of erythrocyte plasma membranes occur in hypertension, and these alterations in lipid composition result in morphological and physiological abnormalities that modify the dynamic properties of erythrocytes and contribute to the pathophysiology of hypertension.
机译：遗传和环境因素可能有助于高血压，这是称为原发性高血压的高血压。高血压是心血管疾病，中风和肾功能衰竭的主要独立危险因素;因此，阐明高血压的病症优异的进一步研究。我们最近报道，高血压患者的血小板和中性粒细胞表现出改变的生物物理特征。在本研究中，我们评估了红细胞血浆膜的主要结构元素是否在具有高血压的个体中改变。使用LC / MS-MS将磷脂（磷脂酰胆碱，磷脂酰乙醇胺，磷脂酰丝氨酸，磷脂酰乙胺，磷脂酰丝氨酸，鞘氨酰胺）和胆固醇含量与具有高血压（HTN）和健康个体（HI）的胆固醇含量的胆固醇含量进行比较。 HTN红细胞含有更高的磷脂酰胆碱，磷脂酰乙醇胺和磷脂酰丝氨酸含量，胆固醇含量低于Hi Erythrocytes。此外，原子力显微镜显示HTN红细胞中的重要形态变化，其反映了使用光学荧光，流式细胞术和光谱法在HTN红细胞中观察到的膜脆性和流动性和更高水平的氧化应激。该研究表明，在高血压中发生对红细胞血浆膜的脂质含量的变化，并且脂质组合物中的这些改变导致形态学和生理异常，其改变红细胞的动态性质，并有助于高血压的病理生理学。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号