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首页> 外文期刊>Biochimica et biophysica acta. Biomembranes >The role of connexin and pannexin containing channels in the innate and acquired immune response
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The role of connexin and pannexin containing channels in the innate and acquired immune response

机译：Connexin和Pannexin在先天和获得的免疫反应中含有渠道的作用

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Abstract Connexin (Cx) and pannexin (Panx) containing channels – gap junctions (GJs) and hemichannels (HCs) – are present in virtually all cells and tissues. Currently, the role of these channels under physiological conditions is well defined. However, their role in the immune response and pathological conditions has only recently been explored. Data from several laboratories demonstrates that infectious agents, including HIV, have evolved to take advantage of GJs and HCs to improve viral/bacterial replication, enhance inflammation, and help spread toxicity into neighboring areas. In the current review, we discuss the role of Cx and Panx containing channels in immune activation and the pathogenesis of several infectious diseases. This article is part of a Special Issue entitled: Gap Junction Proteins edited by Jean Claude Herve. Highlights ? Gap junctions and hemichannels participate in the generation of the innate and acquired immune response. ? Immune cells under resting condition express low to undetectable levels of connexins and pannexin. ? Upon activation immune cells express connexin channels, gap junctions and hemichannels, and pannexin channels to control immune response.
机译：摘要Connexin（CX）和含有通道 - 间隙结（GJS）和血管槽（HCS）的PANNEXIN（PANX） - 几乎存在于所有细胞和组织中。目前，这些渠道在生理条件下的作用明确了。然而，它们在免疫反应和病理条件下的作用仍未探讨。来自若干实验室的数据表明，包括艾滋病毒的传染性药物已经发展起来利用GJS和HCS来改善病毒/细菌复制，增强炎症，帮助将毒性传播到邻近地区。在目前的审查中，我们讨论了CX和Panx含有频道在免疫激活和几种传染病的发病机制中的作用。本文是题为的特殊问题的一部分：Jean Claude Herve编辑的Gap Junction蛋白。强调 ？间隙连接和血管箱参与生成先天和获得的免疫反应。还在静息条件下的免疫细胞表达低至未检测的Connexins和Pannexin水平。还在激活免疫细胞上，表达Cancexin通道，间隙结和血管箱，以及Pannexin通道以控制免疫应答。

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