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首页> 外文期刊>Biochimica et Biophysica Acta. Gene Regulatory Mechanisms >PDYN, a gene implicated in brain/mental disorders, is targeted by REST in the adult human brain
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PDYN, a gene implicated in brain/mental disorders, is targeted by REST in the adult human brain

机译：pdyn是含有大脑/精神障碍的基因，是在成年人脑中的休息靶向

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摘要

The dynorphin κ-opioid receptor system is implicated in mental health and brain/mental disorders. However, despite accumulating evidence that PDYN and/or dynorphin peptide expression is altered in the brain of individuals with brain/mental disorders, little is known about transcriptional control of PDYN in humans. In the present study, we show that PDYN is targeted by the transcription factor REST in human neuroblastoma SH-SY5Y cells and that that interfering with REST activity increases PDYN expression in these cells. We also show that REST binding to PDYN is reduced in the adult human brain compared to SH-SY5Y cells, which coincides with higher PDYN expression. This may be related to MIR-9 mediated down-regulation of REST as suggested by a strong inverse correlation between REST and MIR-9 expression. Our results suggest that REST represses PDYN expression in SH-SY5Y cells and the adult human brain and may have implications for mental health and brain/mental disorders.
机译：Dynorphinκ-Apioid受体系统涉及精神健康和脑/精神障碍。 然而，尽管积累了脑/精神障碍的个体脑中的脑部和/或达氏肽肽表达的证据，但是关于人类PDYN的转录控制很少。 在本研究中，我们表明PDYN由人神经母细胞瘤SH-SENY5Y细胞中的转录因子靶向靶向，并且干扰静止活性的影响增加了这些细胞中的PDYN表达。 我们还表明，与SH-SY5Y细胞相比，成年人脑中的休息与PDEN的结合减少，这与较高的PDYN表达相一致。 这可能与miR-9介导的休息介导的下调，如休息和miR-9表达之间的强逆相关性所示。 我们的研究结果表明，RET抑制了SH-SY5Y细胞和成人人脑中的PDEN表达，可能对心理健康和脑/精神障碍有影响。

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  • 作者

    HenrikssonR.; B?ckmanC.M.; HarveyB.K.; KadyrovaH.; BazovI.; ShippenbergT.S.; BakalkinG.;

  • 作者单位

    Integrative Neuroscience Section Integrative Neuroscience Research Branch NIDA-IRP NIH 333;

    Cellular Neurophysiology Section Cellular Neurobiology Research Branch NIDA-IRP NIH 333 Cassell;

    Neural Protection and Regeneration Section Molecular Neuropsychiatry Research Branch NIDA-IRP;

    Department of Pharmaceutical Biosciences Uppsala University Uppsala Biomedical Centre Box591;

    Department of Pharmaceutical Biosciences Uppsala University Uppsala Biomedical Centre Box591;

    Integrative Neuroscience Section Integrative Neuroscience Research Branch NIDA-IRP NIH 333;

    Department of Pharmaceutical Biosciences Uppsala University Uppsala Biomedical Centre Box591;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 分子生物学;
  • 关键词

    MIR-9; NRSF; PDYN; Prefrontal cortex; REST; SH-SY5Y cell;

    机译：miR-9;nrsf;pdyn;prefrontal cortex;休息;sh-sy5y细胞;

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