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首页> 外文期刊>Burns: Including Thermal Injury >Current concepts on burn wound conversion A review of recent advances in understanding the secondary progressions of burns
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Current concepts on burn wound conversion A review of recent advances in understanding the secondary progressions of burns

机译：目前关于烧伤伤口转换的概念对理解烧伤二次进展的综述近期进步

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摘要

Burn wound conversion describes the process by which superficial partial thickness burns convert into deeper burns necessitating surgical intervention. Fully understanding and thus controlling this phenomenon continues to defy burn surgeons. However, potentially guiding burn wound progression so as to obviate the need for surgery while still bringing about healing with limited scarring is the major unmet challenge. Comprehending the pathophysiologic background contributing to deeper progression of these burns is an essential prerequisite to planning any intervention. In this study, a review of articles examining burn wound progression over the last five years was conducted to analyze trends in recent burn progression research, determine changes in understanding of the pathogenesis of burn conversion, and subsequently examine the direction for future research in developing therapies. The majority of recent research focuses on applying therapies from other disease processes to common underlying pathogenic mechanisms in burn conversion. While ischemia, inflammation, and free oxygen radicals continue to demonstrate a critical role in secondary necrosis, novel mechanisms such as autophagy have also been shown to contribute affect significantly burn progression significantly. Further research will have to determine whether multiple mechanisms should be targeted when developing clinical therapies. (C) 2015 Elsevier Ltd and, ISBI. All rights reserved.
机译：烧伤缠绕转换描述了浅表偏厚燃烧到更深燃烧的过程，需要手术干预。完全理解并因此控制这种现象继续蔑视烧伤外科医生。然而，可能导致烧伤伤口进展，以便避免手术的需求，同时仍然带来有限的疤痕的愈合是主要的未满足挑战。理解促进这些燃烧的更深进展的病理物理学背景是规划任何干预的必要先决条件。在这项研究中，对过去五年来检查伯爵伤口进展的文章进行了审查，以分析近期烧伤进展研究的趋势，确定了了解烧伤转换发病机制的变化，随后研究了发展疗法的未来研究方向。最近的大多数研究侧重于将疗法从其他疾病过程应用于烧伤转换中的共同疾病致病机制。虽然缺血，炎症和游离氧自由基继续在二次坏死中表现出关键作用，但也已被证明诸如自噬之类的新机制可以显着燃烧显着燃烧进展。进一步的研究必须确定在开发临床疗法时应针对多种机制。 （c）2015年Elsevier Ltd和Isbi。版权所有。

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