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Pathogenesis of endometriosis: Interaction between Endocrine and inflammatory pathways

机译：子宫内膜异位症的发病机制：内分泌和炎症途径之间的相互作用

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摘要

Despite an estimated prevalence of 11% in women and plausible historical descriptions dating back to the 17th century, the etiology of endometriosis remains poorly understood. Classical theories of the histological origins of endometriosis are reviewed below. Clinical presentations are variable, and signs and symptoms do not correlate well with the extent of disease. In this summary, we have attempted to synthesize the growing evidence that hormonal and immune factors conspire to activate a local inflammatory microenvironment that encourages endometriosis to persist and elaborate mediators of its two cardinal symptoms: pain and infertility. Surprisingly, in the search for novel therapeutics for medical treatment of endometriosis, some compounds appear to have dual pharmacological functions, simultaneously modifying the endocrine and immune system facets of this complex gynecologic syndrome. We predict that these lead drugs will provide more therapeutic choices for patients in the future.
机译：尽管估计患有11％的女性和可追溯到17世纪的合理的历史描述，但是子宫内膜异位症的病因仍然明白。下面审查了子宫内膜异位症组织学渊源的经典理论。临床介绍是可变的，并且症状和症状与疾病程度没有良好相关。在本发明内容中，我们试图综合滋生和免疫因子的营养性和免疫因素激发激活局部炎症微环境，促进子宫内膜异位症，以持续和精心制定其两种主要症状的介质：疼痛和不孕症。令人惊讶的是，在寻找新宫源性病的医疗治疗的新疗法中，一些化合物似乎具有双重药理学功能，同时改变该复杂的妇科综合征的内分泌和免疫系统刻面。我们预测，这些铅药将来将为未来提供更多的患者治疗选择。

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