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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Endothelial and left ventricular diastolic function in young adults exposed to tobacco
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Endothelial and left ventricular diastolic function in young adults exposed to tobacco

机译：暴露于烟草的年轻成年人内皮和左心室舒张功能

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摘要

Smoking is associated with endothelial and left ventricular diastolic disfunction. We aimed to determine the endothelial and diastolic function in young adults exposed to tobacco smoke and the effects of acute exposure to it. Smokers were considered as cases and non-smokers as controls. Brachial artery diameter, brachial artery flow velocity, and echocardiographic variables were measured. Mean age of the participants was 21 years. Smokers showed significant endothelial dysfunction compared with non-smokers. Arterial dilation mediated by the endothelium was significantly higher in non-smokers than in smokers (p = 0.005). Non-endothelium-mediated arterial dilation was significantly impaired in smokers compared with nonsmokers (p = 0.02). After reactive hyperaemia, there was a significant increase in blood flow in non-smokers (61%) compared with that in smokers (29%). Acute cigarette exposure showed a trend towards left ventricle diastolic disfunction in smokers. Left atrium diameter was significantly higher in smokers than in non-smokers. After acute exposure to cigarette smoke, arterial dilation and brachial flow velocity were lower than those achieved in the abstinence phase (p = 0.005). We concluded that endothelium-dependent arterial dilation is impaired in young smokers and it worsens even after acute exposure to cigarette smoke.
机译：吸烟与内皮和左心室舒张性脱位有关。我们的旨在确定暴露于烟草烟雾的年轻成年人的内皮和舒张功能以及急性暴露对其的影响。吸烟者被认为是案例和非吸烟者作为对照。测量肱动脉直径，肱动脉流速和超声心动图变量。参与者的平均年龄是21年。与非吸烟者相比，吸烟者显示出明显的内皮功能障碍。非吸烟者介导的内皮介导的动脉扩张显着高于吸烟者（P = 0.005）。与非莫克者相比，吸烟者的非内皮介导的动脉扩张显着损害（P = 0.02）。在反应性高血血症后，与吸烟者（29％）相比，非吸烟者（61％）的血流血流显着增加（29％）。急性卷烟曝光显示吸烟者左心室舒张障碍的趋势。吸烟者的左心房直径明显高于非吸烟者。急性暴露于香烟烟雾后，动脉扩张和臂流速低于止动阶段（p = 0.005）的血管流速。我们得出结论，在年轻吸烟者中，内皮依赖性动脉扩张损害，即使在烟雾烟雾暴露后，它也会恶化。

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