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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Endoplasmic reticulum and the microRNA environment in the cardiovascular system
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Endoplasmic reticulum and the microRNA environment in the cardiovascular system

机译:内质网和心血管系统中的microRNA环境

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摘要

Stress responses are important to human physiology and pathology, and the inability to adapt to cellular stress leads to cell death. To mitigate cellular stress and re-establish homeostasis, cells, including those in the cardiovascular system, activate stress coping response mechanisms. The endoplasmic reticulum, a component of the cellular reticular network in cardiac cells, mobilizes so-called endoplasmic reticulum stress coping responses, such as the unfolded protein response. MicroRNAs play an important part in the maintenance of cellular and tissue homeostasis, perform a central role in the biology of the cardiac myocyte, and are involved in pathological cardiac function and remodeling. In this paper, we review a link between endoplasmic reticulum homeostasis and microRNA with an emphasis on the impact on stress responses in the cardiovascular system.
机译:应激反应对人体生理学和病理学是重要的,并且无法适应细胞应激导致细胞死亡。 为了减轻细胞应激并重新建立稳态,细胞,包括心血管系统中的细胞,激活应激应激响应机制。 内质网,心脏细胞中的细胞网状网的组分动员所谓的内质网应激应答,例如展开的蛋白质反应。 MicroRNA在维持细胞和组织稳态中发挥重要组成部分,在心肌细胞的生物学中进行核心作用,并参与病理心功能和重塑。 在本文中,我们审查了内质网稳态和微瘤之间的联系,重点是心血管系统中对压力反应的影响。

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