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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >The role of aspirin and inflammation on reproduction: the EAGeR trial
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The role of aspirin and inflammation on reproduction: the EAGeR trial

机译：阿司匹林和炎症对繁殖的作用：渴望试验

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Inflammation has been linked to several complications in pregnancy, including pregnancy loss. Due to its anti-inflammatory properties, aspirin, a widely available and inexpensive therapy, has potential to help mitigate the negative effects of inflammation along the reproductive pathway. Therefore, the Effects of Aspirin in Gestation and Reproduction (EAGeR) trial was designed to elucidate whether preconception-initiated daily low-dose aspirin would increase the live birth rate in women with 1–2 prior pregnancy losses and no infertility diagnosis and attempting unassisted conception. Here, we present an overview of the collected findings. Low-dose aspirin was associated with an increased live birth rate among women with a single loss at <20 weeks gestation within the past year. When stratified by tertile of C-reactive protein (CRP), a biomarker of inflammation, treatment with aspirin restored a decrement in the live birth rate in women in the highest CRP tertile (relative risk 1.35, 95% confidence interval 1.08–1.67), increasing to similar rates as women of the lower and mid-CRP tertiles. The same effect modification by inflammation status was observed when examining the effect of low-dose aspirin on offspring sex ratio. These results suggest that inflammation plays an important role in reproduction, and that chronic, low-grade inflammation may be amenable to aspirin treatment.
机译：炎症与妊娠的几个并发症有关，包括妊娠损失。由于其抗炎性质，阿司匹林，广泛可用和廉价的治疗，有可能帮助减轻炎症沿生殖途径的负面影响。因此，旨在阐明妊娠和繁殖（急切）试验中阿司匹林在妊娠和繁殖（急切）的试验中的效果，以阐明先进的每日低剂量阿司匹林是否会增加患有1-2例妊娠损失的女性的活产率，并且没有不孕症诊断，并试图独立的概念。在这里，我们概述了收集的结果。低剂量阿司匹林与在过去一年内妊娠的单一损失增加的女性的活产率增加有关。当由C-反应蛋白（CRP）的Tertile分层时，炎症的生物标志物，Aspirin的治疗恢复了最高CRP Tertile中女性的活产率下降（相对风险1.35,95％的置信区间1.08-1.67），随着较低CRP妇女的增加而增加的速率。当检查低剂量阿司匹林对后代性别比的影响时，观察到炎症状态的相同效果改性。这些结果表明，炎症在繁殖中发挥着重要作用，并且慢性低级炎症可享受阿司匹林治疗。

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