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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Caffeine intake increases plasma ketones: an acute metabolic study in humans
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Caffeine intake increases plasma ketones: an acute metabolic study in humans

机译:咖啡因摄入量增加了血浆酮:人类的急性代谢研究

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摘要

Brain glucose uptake declines during aging and is significantly impaired in Alzheimer's disease. Ketones are the main alternative brain fuel to glucose so they represent a potential approach to compensate for the brain glucose reduction. Caffeine is of interest as a potential ketogenic agent owing to its actions on lipolysis and lipid oxidation but whether it is ketogenic in humans is unknown. This study aimed to evaluate the acute ketogenic effect of 2 doses of caffeine (2.5; 5.0 mg/kg) in 10 healthy adults. Caffeine given at breakfast significantly stimulated ketone production in a dose-dependent manner (+88%; +116%) and also raised plasma free fatty acids. Whether caffeine has long-term ketogenic effects or could enhance the ketogenic effect of medium chain triglycerides remains to be determined.
机译:脑葡萄糖摄取在老龄化期间下降,在阿尔茨海默病中受到显着损害。 酮是葡萄糖的主要替代脑燃料,所以它们代表了补偿脑葡萄糖减少的潜在方法。 由于其对脂解和脂质氧化的作用,咖啡因作为潜在的酮糖剂是感兴趣的,但在人类中是否是酮酮是未知的。 本研究旨在评估2剂咖啡因(2.5; 5.0mg / kg)在10名健康成年人中的急性致酮效应。 在早餐时给出的咖啡因显着刺激酮的产量,以剂量依赖性方式(+ 88%; + 116%),也升高了血浆游离脂肪酸。 咖啡因是否具有长期的酮效应或可以增强中链甘油三酯的酮酸效果仍有待确定。

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