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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Trigonelline attenuates hepatic complications and molecular alterations in high-fat high-fructose diet-induced insulin resistance in rats
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Trigonelline attenuates hepatic complications and molecular alterations in high-fat high-fructose diet-induced insulin resistance in rats

机译：三角素抑制高脂高果糖饮食诱导的大鼠胰岛素抗性的肝并发症和分子改变

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摘要

The present study aimed to evaluate the effect of trigonelline (TRG) on the hepatic complications associated with high-fat high-fructose (HFHF) diet-induced insulin resistance (IR) in rats. IR was induced by giving a saturated fat diet and 10% fructose in drinking water to rats for 8 weeks. Insulin-resistant rats were orally treated with TRG (50 and 100 mg/kg), sitagliptin (SIT; 5 mg/kg), or a combination of TRG (50 mg/kg) and SIT (5 mg/kg) for 14 days. Liver homogenates were used for assessment of hepatic lipids, oxidative stress biomarkers, and inflammatory cytokines. Histopathological and DNA cytometry examinations were carried out for hepatic and pancreatic tissues. Hepatic tissues were examined using Fourier-transform infrared spectroscopy for assessment of any molecular changes. Results of the present study revealed that oral treatment of insulin-resistant rats with TRG or TRG in combination with SIT significantly decreased homeostatic model assessment of IR, hepatic lipids, oxidative stress biomarkers, and the inflammatory cytokines. TRG or TRG in combination with SIT ameliorated the histopathological, DNA cytometry, and molecular alterations induced by a HFHF diet. Finally, it can be concluded that TRG has beneficial effects on the hepatic complications associated with IR due to its hypoglycemic effect and antioxidant potential.
机译：本研究旨在评估三谷植物（TRG）对大鼠高脂高果糖（HFHF）饮食诱导的胰岛素抵抗（IR）相关的肝脏并发症的影响。通过在饮用水中给予饱和的脂肪饮食和10％果糖给大鼠诱导18周。用TRG（50和100mg / kg），SitaGlitin（Sit; 5mg / kg）或Trg（50mg / kg）的组合，并静置（5mg / kg）14天的组合14天。肝匀浆用于评估肝脂质，氧化应激生物标志物和炎症细胞因子。对肝癌和胰腺组织进行组织病理学和DNA细胞术检查。使用傅里叶变换红外光谱检查肝组织以评估任何分子变化。本研究结果显示，与TRG或TRG与SIT组合的胰岛素抗性大鼠的口服治疗显着降低了IR，肝脂质，氧化应激生物标志物和炎症细胞因子的稳态模型评估。 TRG或TRG与静止的组合改善了通过HFHF饮食诱导的组织病理学，DNA细胞术和分子改变。最后，可以得出结论，由于其降血糖效应和抗氧化潜力，TRG对与IR相关的肝并发症有益的影响。

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