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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Cannabinoid signaling in health and disease
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Cannabinoid signaling in health and disease

机译：在健康和疾病中的大麻素信号传导

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摘要

Cannabis sativa has long been used for medicinal purposes. To improve safety and efficacy, compounds from C. sativa were purified or synthesized and named under an umbrella group as cannabinoids. Currently, several cannabinoids may be prescribed in Canada for a variety of indications such as nausea and pain. More recently, an increasing number of reports suggest other salutary effects associated with endogenous cannabinoid signaling including cardioprotection. The therapeutic potential of cannabinoids is therefore extended; however, evidence is limited and mechanisms remain unclear. In addition, the use of cannabinoids clinically has been hindered due to pronounced psychoactive side effects. This review provides an overview on the endocannabinoid system, including known physiological roles, and conditions in which cannabinoid receptor signaling has been implicated.
机译：大麻苜蓿已长期用于药用目的。 为了提高安全性和疗效，将来自C.苜蓿的化合物纯化或合成并命名为大麻素。 目前，可以在加拿大开展几种大麻素，以获得各种适应症，如恶心和疼痛。 最近，越来越多的报告表明与包括心脏保护的内源大麻素信号传导相关的其他有益效应。 因此延长了大麻素的治疗潜力; 但是，证据是有限的，并且机制仍然不清楚。 此外，由于明显的精神活性副作用，使用大麻素临床临床上受到阻碍。 该综述提供了对内胆蛋白系统的概述，包括已知的生理作用以及大麻素受体信号传导的条件。

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