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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Resveratrol promotes recovery of immune function of immunosuppressive mice by activating JNK/NF-kappa B pathway in splenic lymphocytes
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Resveratrol promotes recovery of immune function of immunosuppressive mice by activating JNK/NF-kappa B pathway in splenic lymphocytes

机译：通过在脾淋巴细胞中激活JNK / NF-Kappa B途径促进免疫抑制小鼠免疫功能的回收率

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摘要

Resveratrol, a natural compound found in over 70 plants, is known to possess immunoregulatory effects and antiinflammatory activity. It has been shown that resveratrol has regulatory effects on different signaling pathways in different diseases. However, few reports have evaluated the effects of resveratrol on reinforcing immunity recovery via activating nuclear factor-kappa B (NF-kappa B) pathway and Jun N-terminal kinases (JNK) pathway. The present study aimed to assess immune-enhancing activity and underlying mechanism of resveratrol in immunosuppressive mice. Previously, we reported that resveratrol could promote mouse spleen lymphocyte functions to recover the immune system effectively. In the present study, we show that resveratrol could upregulate the expressions of NF-kappa B, I kappa B kinase, JNK, and c-jun in splenic lymphocytes of immunosuppressive mice. Taken together, our results indicate that resveratrol could promote recovery of immunologic function in immunosuppressive mice by activating JNK/ NF-kappa B pathway.
机译：已知已知在70多种植物中发现的天然化合物具有免疫调节效果和抗炎活性。已经表明，白藜芦醇对不同疾病的不同信号途径具有调节作用。然而，很少有报告评估了白藜芦醇对通过激活核因子-Kappa B（NF-Kappa B）途径和Jun N-末端激酶（JNK）途径来加强免疫回收的影响。本研究旨在评估白藜芦醇在免疫抑制小鼠中的免疫增强活性和潜在机制。以前，我们报道了白藜芦醇可以促进小鼠脾脏淋巴细胞功能，以有效地回收免疫系统。在本研究中，我们表明白藜芦醇可以上调免疫抑制小鼠的脾淋巴细胞中NF-Kappa B，I Kappa B激酶，JNK和C-Jun的表达。我们的结果表明，通过激活JNK / NF-Kappa B途径，白藜芦醇可以促进免疫抑制小鼠中免疫功能的恢复。

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  • 作者

    Lai Xin; Cao Mei; Song Xu; Jia Renyong; Zou Yuanfeng; Li Lixia; Liang Xiaoxia; He Changliang; Yin Lizi; Yue Guizhou; Ye Gang; Yin Zhongqiong;

  • 作者单位

    Sichuan Agr Univ Coll Vet Med Nat Med Res Ctr Chengdu 611130 Peoples R China;

    Sichuan Prov Peoples Hosp Core Lab Chengdu 610072 Peoples R China;

    Sichuan Agr Univ Coll Vet Med Nat Med Res Ctr Chengdu 611130 Peoples R China;

    Sichuan Agr Univ Key Lab Anim Dis &

    Human Hlth Sichuan Prov Chengdu 611130 Peoples R China;

    Sichuan Agr Univ Coll Vet Med Nat Med Res Ctr Chengdu 611130 Peoples R China;

    Sichuan Agr Univ Coll Vet Med Nat Med Res Ctr Chengdu 611130 Peoples R China;

    Sichuan Agr Univ Coll Vet Med Nat Med Res Ctr Chengdu 611130 Peoples R China;

    Sichuan Agr Univ Coll Vet Med Nat Med Res Ctr Chengdu 611130 Peoples R China;

    Sichuan Agr Univ Coll Vet Med Nat Med Res Ctr Chengdu 611130 Peoples R China;

    Sichuan Agr Univ Coll Sci Yaan 625014 Peoples R China;

    Sichuan Agr Univ Coll Vet Med Nat Med Res Ctr Chengdu 611130 Peoples R China;

    Sichuan Agr Univ Coll Vet Med Nat Med Res Ctr Chengdu 611130 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 药理学;
  • 关键词

    resveratrol; JNK/NF-kappa B pathway; spleen lymphocyte; immunosuppressive mice;

    机译：白藜芦醇;JNK / NF-Kappa B途径;脾脏淋巴细胞;免疫抑制小鼠;

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