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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Arachidonic acid epoxygenase and 12(S)-lipoxygenase: evidence of their concerted involvement in ductus arteriosus constriction to oxygen.
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Arachidonic acid epoxygenase and 12(S)-lipoxygenase: evidence of their concerted involvement in ductus arteriosus constriction to oxygen.

机译：花生醛酸环氧树脂和12（S） - 苯并钠酶：其齐心协力参与导管动脉瘤的氧气对氧气。

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摘要

Oxygen promotes closure of the ductus arteriosus at birth. We have previously presented a scheme for oxygen action with a cytochrome P450 (CYP450) hemoprotein and endothelin-1 (ET-1) being, respectively, sensor and effector, and a hypothetical monooxygenase product serving as a coupling link. We have also found in the vessel arachidonic acid (AA) 12(S)-lipoxygenase (12-lipoxygenase) undergoing upregulation at birth. Here, we examined the feasibility of a sensor-to-effector messenger originating from AA monooxygenase and 12-lipoxygenase pathways. The epoxygenase inhibitor, N-methylsulfonyl-6-(2-)hexanamide, suppressed the tonic contraction of ductus to oxygen. A similar effect was obtained with 12-lipoxygenase inhibitors baicalein and PD 146176. By contrast, none of the inhibitors modified the endothelin-1 contraction. Furthermore, an AA omega-hydroxylation product, 20-hydroxyeicosatetraenoic acid (20-HETE), reportedly responsible for oxygen contraction in the systemic microvasculature, had no such effect on the ductus. We conclude that AA epoxygenase and 12-lipoxygenase jointly produce a hitherto uncharacterized compound acting as oxygen messenger in the ductus.
机译：氧气在出生时促进了导管蛛丝的闭合。我们之前介绍了一种具有细胞色素P450（CYP450）血栓素和内皮素-1（ET-1）的氧动作的方案，分别是传感器和效应器，以及用作偶联链路的假想单氧基酶产物。我们还发现在出生时正在进行上调的血管花生素酸（AA）12（S） - 苯并苯基酶（12-脂氧基酶）。在这里，我们研究了来自AA单氧基酶和12-脂氧基酶途径的传感器到效应信使的可行性。环氧树脂酶抑制剂，N-甲基磺酰基-6-（2-）己酰胺，抑制了导管对氧气的滋补收缩。用12-脂氧基酶抑制剂Baicalein和Pd 146176获得类似的效果。相比之下，没有抑制剂没有修饰内皮素-1收缩。此外，据报道，AA OMega-羟基化产物，20-羟基喹硫代甲酸（20-HETE）对系统微血管系统中的氧收缩负责，对导管没有这种作用。我们得出结论，AA环氧树脂酶和12-脂氧合酶共同产生迄今为止的非特征化合物作为氧气信使在导管中。

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