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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Resveratrol ameliorates the cyclosporine-induced vascular and renal impairments: possible impact of the modulation of renin-angiotensin system
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Resveratrol ameliorates the cyclosporine-induced vascular and renal impairments: possible impact of the modulation of renin-angiotensin system

机译：白藜芦醇改善环孢菌素诱导的血管和肾损伤：调节肾素 - 血管紧张素系统的可能影响

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Cyclosporine, an immunosuppressive drug, exhibits a toxic effect on renal and vascular systems. The present study investigated whether resveratrol treatment alleviates renal and vascular injury induced by cyclosporine. Cyclosporine (25 mg/kg per day, s.c.) was given for 7 days to rats either alone or in combination with resveratrol (10 mg/kg per day, i.p.). Relaxation and contraction responses of aorta were examined. Serum levels of blood urea nitrogen, creatinine, angiotensin II, and angiotensin 1-7 were measured. Histopathological examinations as well as immunostaining for 4-hydroxynonenal and nitrotyrosine were performed in the kidney. RNA expressions of renin-angiotensin system components were also measured in renal and aortic tissues. Cyclosporine decreased the endothelium-dependent relaxation and increased vascular contraction in the aorta. It caused renal tubular degeneration and increased immunostaining for 4-hydroxynonenal, an oxidative stress marker. Cyclosporine also caused upregulations of the vasoconstrictive renin-angiotensin system components in renal (angiotensin-converting enzyme) and aortic (angiotensin II type 1 receptor) tissues. Resveratrol co-treatment prevented the cyclosporine-related deteriorations. Moreover, it induced the expressions of vasodilatory effective angiotensin-converting enzyme 2 and angiotensin II type 2 receptor in aorta and kidney, respectively. We conclude that resveratrol may be effective in preventing cyclosporine-induced renal tubular degeneration and vascular dysfunction at least in part by modulating the renin-angiotensin system.
机译：环孢菌素是免疫抑制药物，对肾和血管系统具有毒性作用。本研究研究了白藜芦醇治疗是否可缓解环孢菌素诱导的肾和血管损伤。环孢菌素（每天25mg / kg，s.c.）给予单独的大鼠或与白藜芦醇（每天10mg / kg，i.p.）组合给予大鼠7天。检查主动脉的放松和收缩响应。测量血清尿素氮，肌酐，血管紧张素II和血管紧张素1-7水平。在肾脏中进行组织病理学检查以及4-羟基诺和硝基硝基的免疫染料。在肾和主动脉组织中也测量了肾素 - 血管紧张素系统组分的RNA表达。环孢菌素降低了依赖于内皮依赖性的弛豫和主动脉血管收缩。它导致肾小管变性和4-羟基诺的免疫染色，氧化应激标记物增加。环孢菌素还引起肾（血管紧张素转换酶）和主动脉（血管紧张素II型1受体）组织中血管收缩性肾素 - 血管紧张素系统组分的上调。白藜芦醇共同治疗可防止环孢孢菌相关的劣化。此外，它诱导分别在主动脉和肾的血管舒张有效血管紧张素转化酶2和血管紧张素II型受体表达。我们得出结论，通过调节肾素 - 血管紧张素系统，白藜芦醇至少可以至少部分地防止环孢菌素诱导的肾小管造环和血管功能障碍。

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