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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Effects of beta-adrenergic receptor blockers on cardiac function: a comparative study in male versus female rats.
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Effects of beta-adrenergic receptor blockers on cardiac function: a comparative study in male versus female rats.

机译：β-肾上腺素能受体阻滞剂对心脏功能的影响：男性对比雌性大鼠的比较研究。

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In heart disease, differences exist between women and men with respect to the impact of risk factors, symptoms, and therapeutic responses. The use of beta-adrenergic receptor blockers is now well established in the treatment of mild and moderate systolic heart failure. Although there are significant differences among agents, their clinical effects are predictable. To address the question of sex disparities in the heart, however, we investigated the effect of treatment with the nonselective beta-blockers timolol and propranolol on mechanical and electrical function of heart preparations from male and female rats. We examined the long-term effects of intragastric treatment with timolol (5 mg/kg per day) or propranolol (25 mg/kg per day) for 7 months on the hemodynamic and intracellular action potential parameters of the heart. Chronic administration of timolol but not propranolol produced a significant increase in the baseline activity of the left ventricular developed pressure (LVDP) in both male and female rats with no significant effect on the left ventricular end-diastolic pressure. Timolol or propranolol treatment of male rats and timolol but not propranolol treatment of female rats induced significant shortening in the repolarization phases of action potentials recorded from left ventricular papillary muscle strips of the hearts. The responses of LVDP to beta-adrenergic stimulation were similar in timolol- or propranolol-treated or untreated male rats. On the other hand, timolol treatment markedly increased, and propranolol treatment significantly decreased, the responses of increase in LVDP in female rats. Our results suggest that although treatment with beta-blockers for 7 months confirmed the role of the beta-adrenergic pathway in heart function, there are marked differences in the effects of individual beta-blockers on heart physiology. Sex differences should be taken into consideration when using beta-blockers during experimental studies and clinical therapy.
机译：在心脏病中，妇女与男性之间存在危险因素，症状和治疗反应影响的差异。现在使用β-肾上腺素能受体阻滞剂在治疗温和和中度收缩心力衰竭的情况下已经很好地建立。虽然药剂之间存在显着差异，但它们的临床效果是可预测的。然而，为了解决内心性差异的问题，我们研究了对非选择性β-封锁氏乳氏炎蒂莫尔和普萘洛尔治疗的影响，从雄性和雌性大鼠心脏制剂的机械和电气功能。我们检查了蒂莫尔（每天5mg / kg）或普萘洛尔（每天25mg / kg）的长期效果7个月的心脏血流动力学和细胞内动作潜在参数。氏乳醇但不是丙醇的慢性施用在雄性和雌性大鼠中产生左心室发育压力（LVDP）的基线活动显着增加，对左心室舒张压无显着影响。幼种子或普萘洛尔治疗雄性大鼠和乳醇，但不是雌性大鼠的丙醇醇处理诱导在从左心室乳头肌肉条记录的动作电位的再振荡阶段中缩短显着缩短。 LVDP对β-肾上腺素能刺激的反应在蒂罗尔或普罗兰醇处理或未治疗的雄性大鼠中相似。另一方面，蒂莫尔治疗明显增加，普萘洛尔治疗显着降低，雌性大鼠LVDP增加的反应。我们的研究结果表明，虽然用β-托运器治疗7个月确认了β-肾上腺素能途径在心脏功能中的作用，但在心脏生理中的个体β阻滞剂的影响有明显差异。在实验研究和临床疗法中使用β受体阻滞剂时，应考虑性差异。

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