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首页> 外文期刊>Acta oncologica. >Classical pathological variables recorded in the Danish Breast Cancer Cooperative Group's register 1978-2006.
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Classical pathological variables recorded in the Danish Breast Cancer Cooperative Group's register 1978-2006.

机译：1978-2006年丹麦乳腺癌合作组织注册簿中记录的经典病理变量。

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摘要

The Danish Breast Cancer Cooperative Group's register containing data from about 75 000 patients undergoing surgery for primary invasive breast cancer from 1978-2006 has been examined for classical pathological variables. During that period the diagnostic approach of malignant breast tumours experienced a major shift from invasive surgical procedures to non invasive procedures with an increase of the proportion of both fine needle aspiration biopsy and core needle biopsy. According to variation in tumour size there has been a slight increase in tumours <10 mm and a significant decrease in tumours >50mm from 7 to 4%. The distribution of the histological subtypes of malignant breast tumours has been almost unchanged. We found however a significant increase in the number of high grade tumours. A large increase in the number of removed axillary lymph nodes from 1989-2001 is related to improved surgical procedure. The subsequent decline from 2002-2006 is the result of the introduction of the sentinel node technique. In the five-year period 2002-2006 following the introduction of sentinel node technique, the frequency of patients having at least one lymph node metastases (48.7%) was higher than in the preceding five-year period 1997-2001 (44.4%, p=0.0087).
机译：丹麦乳腺癌合作组织小组的登记册包含了1978-2006年约75,000例接受原发性浸润性乳腺癌手术的患者的数据，并进行了经典病理学检查。在此期间，随着细针穿刺活检和核心针穿刺活检比例的增加，恶性乳腺肿瘤的诊断方法经历了从有创手术到无创手术的重大转变。根据肿瘤大小的变化，<10 mm的肿瘤略有增加，而> 50 mm的肿瘤则显着减少，从7％降至4％。恶性乳腺肿瘤的组织学亚型分布几乎没有变化。然而，我们发现高级别肿瘤的数量显着增加。从1989年至2001年，腋窝淋巴结切除的数量大量增加与手术程序的改善有关。 2002-2006年随后的下降是由于引入了前哨节点技术。在采用前哨淋巴结转移技术的2002-2006年的五年期间，发生至少一个淋巴结转移的患者的发生频率（48.7％）高于前一个1997-2001年的五年期间（44.4％，p = 0.0087）。

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