• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Acta oncologica. >Genetic variations in DNA repair genes, radiosensitivity to cancer and susceptibility to acute tissue reactions in radiotherapy-treated cancer patients.
【24h】

Genetic variations in DNA repair genes, radiosensitivity to cancer and susceptibility to acute tissue reactions in radiotherapy-treated cancer patients.

机译：DNA修复基因的遗传变异，对癌症的放射敏感性和对接受放射治疗的癌症患者的急性组织反应的敏感性。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Ionizing radiation is a well established carcinogen for human cells. At low doses, radiation exposure mainly results in generation of double strand breaks (DSBs). Radiation-related DSBs could be directly linked to the formation of chromosomal rearrangements as has been proven for radiation-induced thyroid tumors. Repair of DSBs presumably involves two main pathways, non-homologous end joining (NHEJ) and homologous recombination (HR). A number of known inherited syndromes, such as ataxia telangiectasia, ataxia-telangiectasia like-disorder, radiosensitive severe combined immunodeficiency, Nijmegen breakage syndrome, and LIG4 deficiency are associated with increased radiosensitivity and/or cancer risk. Many of them are caused by mutations in DNA repair genes. Recent studies also suggest that variations in the DNA repair capacity in the general population may influence cancer susceptibility. In this paper, we summarize the current status of DNA repair proteins as potential targets for radiation-induced cancer risk. We will focus on genetic alterations in genes involved in HR- and NHEJ-mediated repair of DSBs, which could influence predisposition to radiation-related cancer and thereby explain interindividual differences in radiosensitivity or radioresistance in a general population.
机译：电离辐射是人类细胞公认的致癌物。在低剂量下，辐射暴露主要导致双链断裂（DSB）的产生。辐射相关的DSB可以直接与染色体重排的形成联系起来，正如已经证明了辐射诱发的甲状腺肿瘤。 DSB的修复大概涉及两个主要途径，非同源末端连接（NHEJ）和同源重组（HR）。许多已知的遗传综合征，例如共济失调毛细血管扩张症，共济失调-毛细血管扩张症，放射敏感性严重的联合免疫缺陷，奈梅亨断裂综合征和LIG4缺乏症与放射敏感性和/或癌症风险增加相关。其中许多是由DNA修复基因的突变引起的。最近的研究还表明，一般人群中DNA修复能力的变化可能会影响癌症的易感性。在本文中，我们总结了DNA修复蛋白的现状，将其作为辐射诱发的癌症风险的潜在靶标。我们将关注与HR和NHEJ介导的DSB修复有关的基因的遗传改变，这可能会影响与辐射相关的癌症的易感性，从而解释一般人群中放射敏感性或放射抵抗性的个体差异。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号