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首页> 外文期刊>International Journal of Radiation Biology: Covering the Physical, Chemical, Biological, and Medical Effects of Ionizing and Non-ionizing Radiations >No correlation between radiosensitivity or double-strand break repair capacity of normal fibroblasts and acute normal tissue reaction after radiotherapy of breast cancer patients.
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No correlation between radiosensitivity or double-strand break repair capacity of normal fibroblasts and acute normal tissue reaction after radiotherapy of breast cancer patients.

机译：正常的成纤维细胞的放射敏感性或双链断裂修复能力与乳腺癌患者放疗后的急性正常组织反应之间没有相关性。

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摘要

The aim was to study the relationship between cellular radiosensitivity or double-strand break (dsb) repair capacity of skin fibroblasts and the extent of acute reaction after radiotherapy for breast cancer. The study was performed with 25 breast cancer patients submitted to the radiotherapy unit of the Egyptian National Cancer Institute after conserving surgery. Dermal fibroblasts, established from skin biopsies, were used to determine the cellular radiosensitivity via colony assay and the capacity of dsb repair by constant-field gel electrophoresis. Acute reactions were scored using the Radiation Therapy Oncology Group (RTOG) classification. The spectrum of acute reactions varied from grade 1 to 4, whereby most patients developed a grade 1 reaction after total doses ranging between 46 and 70 Gy. Skin fibroblasts showed a pronounced variation in both cellular radiosensitivity expressed as the mean inactivation dose (Dbar) (coefficient of variation, CV=25%) as well as in the number of residual dsb (CV=33%) with no significant correlation between these two endpoints (r2=0.20, p=0.14). Both parameters did not correlate with the extent of acute reaction of the respective patient. The data obtained indicate that the sensitivity of fibroblasts measured either by colony assay or by dsb repair capacity is not a major parameter determining the extent of acute reaction after radiotherapy of breast cancer patients.
机译：目的是研究皮肤成纤维细胞的细胞放射敏感性或双链断裂（dsb）修复能力与乳腺癌放射治疗后急性反应程度之间的关系。这项研究是对25名乳腺癌患者进行了保留手术后提交埃及国家癌症研究所放疗部门的。通过皮肤活检建立的皮肤成纤维细胞用于通过菌落测定确定细胞的放射敏感性，并通过恒定场凝胶电泳确定dsb修复的能力。使用放射治疗肿瘤学组（RTOG）分类对急性反应进行评分。急性反应的范围从1级到4级不等，因此大多数患者在46至70 Gy的总剂量后发生1级反应。皮肤成纤维细胞在以平均灭活剂量（Dbar）（变异系数，CV = 25％）以及残留dsb数量（CV = 33％）表示的细胞放射敏感性中均表现出明显的变化，两者之间无显着相关性两个端点（r2 = 0.20，p = 0.14）。这两个参数与各自患者的急性反应程度无关。获得的数据表明，通过集落测定或dsb修复能力测量的成纤维细胞敏感性不是决定乳腺癌患者放疗后急性反应程度的主要参数。

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