It's All About MEis: Menin-MLL Inhibition Eradicates NPM1-Mutated and MLL-Rearranged Acute Leukemias in Mice

Gundry Michael C.; Goodell Margaret A.; Brunetti Lorenzo

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It's All About MEis: Menin-MLL Inhibition Eradicates NPM1-Mutated and MLL-Rearranged Acute Leukemias in Mice

机译：这一切都是关于梅斯：menin-mll抑制在小鼠中删除了NPM1突变和MLL重新排列的急性白血病

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Several acute myeloid leukemia genetic sub-types converge on high expression of HOX genes, critical for their self-renewal. A new orally bioavailable Menin-MLL inhibitor (VTP-50469) appears to promote their differentiation through direct effects on the HOX cofactor MEIS1, paving the way for clinical trials.

机译：几种急性髓性白血病遗传子类型会聚在Hox基因的高表达上，对其自我更新至关重要。新的口服生物可利用的Menin-MLM-MLL抑制剂（VTP-50469）似乎通过直接对Hox Cofactor Meis1的直接影响来促进它们的差异，为临床试验铺平道路。

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《Cancer Cell》 |2020年第3期|共4页
作者
Gundry Michael C.; Goodell Margaret A.; Brunetti Lorenzo;
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Baylor Coll Med Mol &

Cellular Biol Houston TX 77030 USA;

Baylor Coll Med Mol &

Cellular Biol Houston TX 77030 USA;

Univ Perugia Dept Med Perugia Italy;

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正文语种 eng
中图分类肿瘤学;
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1. It's All About MEis: Menin-MLL Inhibition Eradicates NPM1-Mutated and MLL-Rearranged Acute Leukemias in Mice [J] . Gundry Michael C., Goodell Margaret A., Brunetti Lorenzo Cancer Cell . 2020,第3期

机译：这一切都是关于梅斯：menin-mll抑制在小鼠中删除了NPM1突变和MLL重新排列的急性白血病
2. PBX3 and MEIS1 Cooperate in Hematopoietic Cells to Drive Acute Myeloid Leukemias Characterized by a Core Transcriptome of the MLL-Rearranged Disease [J] . Li Zejuan, Chen Ping, Su Rui, Cancer research: The official organ of the American Association for Cancer Research, Inc . 2016,第3期

机译：PBX3和MEIS1在造血细胞中合作以驱动以MLL重排疾病的核心转录组为特征的急性髓细胞性白血病
3. An Fc-engineered CD19 antibody eradicates MRD in patient-derived MLL-rearranged acute lymphoblastic leukemia xenografts [J] . Schewe Denis M., Alsadeq Ameera, Sattler Cornelia, Blood: The Journal of the American Society of Hematology . 2017,第13期

机译：FC工程化的CD19抗体在患者衍生的MLL重新排列的急性淋巴细胞白血病异种移植物中消除了MRD
4. Modelling Inhibition of AKT Phosphorylation in Acute Myeloid Leukemia [C] . Y.A. Adi, F. Adi-Kusumo, L. Aryati, Conference on Fundamental and Applied Science for Advanced Technology . 2016

机译：急性髓性白血病中AKT磷酸化的建模抑制作用
5. Differentiation arrest by HoxA9, Meis1, Nup98-HoxA9 and E2a-Pbx1 homeodomain transcription factors: The pathogenesis of a subset of acute leukemia. [D] . Calvo, Katherine Rainsford. 2001

机译：HoxA9，Meis1，Nup98-HoxA9和E2a-Pbx1同源域转录因子的分化停滞：急性白血病子集的发病机制。
6. Down-regulation of homeobox genes MEIS1 and HOXA in MLL-rearranged acute leukemia impairs engraftment and reduces proliferation [O] . Kira Orlovsky, Alexander Kalinkovich, Tanya Rozovskaia, 2011

机译：下调MLL重排的急性白血病中同源异型框基因MEIS1和HOXA的下调会损害植入并减少增殖
7. It’s All About MEis: Menin-MLL Inhibition Eradicates NPM1-Mutated and MLL-Rearranged Acute Leukemias in Mice [O] . Michael C. Gundry, Margaret A. Goodell, Lorenzo Brunetti 2020

机译：这一切都是关于梅斯：menin-mll抑制在小鼠中删除了NPM1突变和MLL重新排列的急性白血病

It's All About MEis: Menin-MLL Inhibition Eradicates NPM1-Mutated and MLL-Rearranged Acute Leukemias in Mice

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