The Crusade against Mutant p53: Does the COMPASS Point to the Holy Grail?

Abraham Christopher G.; Espinosa Joaquin M.

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The Crusade against Mutant p53: Does the COMPASS Point to the Holy Grail?

机译：对阵突变体p53的十字军事：指南针指向圣杯吗？

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Mutations in the TP53 gene not only inactivate its tumor suppressor function but also confer this transcription factor with gain-of-function oncogenic properties. A recent paper by Zhu and colleagues reveals a novel molecular pathway driven by mutant p53 and the COMPASS chromatin-modifying complex that is amenable to pharmacological inhibition.

机译：TP53基因中的突变不仅灭活其肿瘤抑制功能，而且还赋予该转录因子，其具有功能性致癌性能。朱和同事最近的纸张揭示了由突变P53驱动的新型分子途径和染色体改性复合物，其可用于药理学抑制。

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《Cancer Cell》 |2015年第4期|共2页
作者
Abraham Christopher G.; Espinosa Joaquin M.;
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Univ Colorado Denver Sch Med Linda Crnic Inst Syndrome Aurora CO 80045 USA;

Univ Colorado Denver Sch Med Linda Crnic Inst Syndrome Aurora CO 80045 USA;

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原文格式 PDF
正文语种 eng
中图分类肿瘤学;
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专利

1. The Crusade against Mutant p53: Does the COMPASS Point to the Holy Grail? [J] . Abraham Christopher G., Espinosa Joaquin M. Cancer Cell . 2015,第4期

机译：对抗突变p53的十字军东征：指南针是否指向圣杯？
2. Reply from Authors re: Bertrand Tombal. Zometa european study (ZEUS): Another failed crusade for the holy grail of prostate cancer bone metastases prevention? Eur Urol 2015;67:492-4: ZEUS: the quest for the holy grail of prostate cancer bone metastases prevention continues [J] . Anup Patel, Manfred Wirth Indian heart journal . 2015,第3期

机译：作者回复Re：Bertrand Tombal。 Zometa欧洲学习（Zeus）：另一种失败的前列腺癌骨转移预防爪索的十字军划线？ 2015年欧元乌尔尔2015; 67：492-4：宙斯：寻求前列腺癌骨转移的圣杯继续预防
3. Fibroblast growth factor 23 and the quest for the Holy Grail in heart failure: will the Crusaders be forced to surrender? [J] . European journal of heart failure: journal of the Working Group on Heart Failure of the European Society of Cardiology . 2020,第4期

机译：成纤维细胞生长因子23和对心灵失效的圣杯的任务：十字军会被迫投降吗？
4. Low Threshold of Destabilization for Loss of Tumor Suppressor Activity of p53: A Quantitative Analysis of p53 Tetramerization Domain Mutants [C] . Rui Kamada, Takao Nomura, Yoshiro Chuman Japanese peptide symposium . 2011

机译：P53肿瘤抑制剂损失损失低阈值的稳定性：P53四聚化结构域突变体的定量分析
5. Comparing mutant p53 and a wild-type p53 isoform, p47: Rationale for the selection of mutant p53 in tumours. [D] . Marini, Wanda. 2009

机译：比较突变体p53和野生型p53同种型，p47：选择肿瘤中突变体p53的原理。
6. Taxing Sugar-Sweetened Beverages: Not a Holy Grail but a Cup at Least Half Comment on Food Taxes: A New Holy Grail? [O] . Jason P. Block, Walter C. Willett 2013

机译：对含糖饮料征税：不是圣杯而是至少要喝一杯关于食品税：新的圣杯？的评论
7. The Crusade against Mutant p53: Does the COMPASS Point to the Holy Grail? [O] . Abraham Christopher G., Espinosa Joaquín M. 2015

机译：对抗突变p53的十字军东征：COMPASS是否指向圣杯？

The Crusade against Mutant p53: Does the COMPASS Point to the Holy Grail?

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