Tackling Resistance to PI3K Inhibition by Targeting the Epigenome

Koren Shany; Bentires-Alj Mohamed

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Tackling Resistance to PI3K Inhibition by Targeting the Epigenome

机译：通过靶向外形组织来解决对PI3K抑制的抗性

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Phosphoinositide-3-kinase (PI3K) pathway inhibitors have emerged as promising therapeutic agents for estrogen receptor (ER alpha)-positive breast cancers. However, incipient resistance limits the clinical benefit. Toska and colleagues identified that the epigenetic regulator KMT2D enhances ER alpha activity in BYL719-treated PIK3CA mutant breast cancer, leading to a rationale for targeting the epigenome and PI3K signaling.

机译：磷酸阳性-3-激酶（PI3K）途径抑制剂已成为雌激素受体（ERα） - 阳性乳腺癌的有前途治疗剂。然而，初始电阻限制了临床益处。 TOSKA及其同事认为，表观遗传调节剂KMT2D在BYL719治疗的PIK3CA突变乳腺癌中增强了ERα活性，导致靶向外观蛋白酶组和PI3K信号传导的理由。

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《Cancer Cell》 |2017年第5期|共3页
作者
Koren Shany; Bentires-Alj Mohamed;
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Univ Basel Univ Basel Hosp Dept Biomed CH-4031 Basel Switzerland;

Univ Basel Univ Basel Hosp Dept Biomed CH-4031 Basel Switzerland;

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正文语种 eng
中图分类肿瘤学;
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1. Tackling Resistance to PI3K Inhibition by Targeting the Epigenome [J] . Koren Shany, Bentires-Alj Mohamed Cancer Cell . 2017,第5期

机译：通过靶向外形组织来解决对PI3K抑制的抗性
2. CRLF2 Rearrangement Status in Ph-like ALL Predicts Intrinsic Glucocorticoid Resistance In Vitro that is Reversible with Targeted MAPK and PI3K Pathway Inhibition [J] . Meyer Lauren K., Delgado-Martin Cristina, Maude Shannon L., Blood: The Journal of the American Society of Hematology . 2016,第22期

机译：类Ph的ALL中的CRLF2重排状态可预测具有靶向MAPK和PI3K途径抑制作用可逆的内在性糖皮质激素抵抗
3. Antibody targeting of HER2/HER3 signaling overcomes heregulin-induced resistance to PI3K inhibition in prostate cancer [J] . Poovassery Jayakumar S., Kang Jeffrey C., Kim Dongyoung, International Journal of Cancer =: Journal International du Cancer . 2015,第2期

机译：靶向HER2 / HER3信号的抗体克服了调蛋白诱导的前列腺癌对PI3K抑制的抗性
4. The Role of the PI3K Pathway in Anti-IgM (Anti-i) - ensitive and -Resistant B-cell Lymphomas Failure to Disengage PI3K Pathway Signaling Confers i-fi Resistance on the CH12 B Cell Lymphoma [C] . Gregory B. Carey, Laura Tonnetti, David W. Scott International Symposium on Programmed Cell Death . 2003

机译：PI3K途径在抗IgM（抗IgM（抗-Ig）的作用 - 最终和 - 抗生素B细胞淋巴瘤未脱离PI3K途径信号传导对CH12 B细胞淋巴瘤的I-FI阻力
5. Overcoming Anti-Estrogen Resistance in Estrogen Receptor (ER)-Positive Breast Cancer: Rational Targeting of Phosphatidylinositol 3-Kinase (PI3K) and the Resurrection of Estrogen Therapy [D] . Hosford, Sarah 2018

机译：克服雌激素受体（ER）阳性乳腺癌中的抗雌激素抵抗：磷脂酰肌醇3-激酶（PI3K）的合理靶向和雌激素疗法的复活
6. Identifying and targeting cancer stem cells in leiomyosarcoma: prognostic impact and role to overcome secondary resistance to PI3K/mTOR inhibition [O] . Benjamin Fourneaux, Aurélien Bourdon, Bérengère Dadone, 2019

机译：鉴定和靶向平滑肌肉肉瘤中的癌症干细胞：对PI3K / mTOR抑制的继发耐药性的预后影响和作用
7. Tackling Resistance to PI3K Inhibition by Targeting the Epigenome [O] . Shany Koren, Mohamed Bentires-Alj 2017

机译：通过靶向外形组织来解决对PI3K抑制的抗性
8. Approaching Resistance to Targeted Inhibition of PI3K in Breast Cancer [R] . Ilic, N. 2011

机译：接近对乳腺癌中靶向抑制pI3K的抗性

Tackling Resistance to PI3K Inhibition by Targeting the Epigenome

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