HDAC Inhibitors Finally Open Up: Chromatin Accessibility Signatures of CTCL

Ott Christopher J.; Wu Catherine J.

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HDAC Inhibitors Finally Open Up: Chromatin Accessibility Signatures of CTCL

机译：HDAC抑制剂最终开放：CTCL的染色质辅助性签名

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In this issue of Cancer Cell, Qu et al. describe the chromatin accessibility profiles of cutaneous T cell lymphoma, with dynamic assessments of response and resistance to histone deacetylase inhibitor therapy. Their "personal regulome" analysis framework reveals chromatin features that may be predictive of clinical response to epigenetic therapy.

机译：在这个问题中癌细胞，qu等。描述皮肤T细胞淋巴瘤的染色质脱离性曲线，具有对响应和抗性的动态评估，对组蛋白脱乙酰酶抑制作用治疗。他们的“个人正规”分析框架揭示了染色质特征，可预测对表观遗传疗法的临床反应。

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《Cancer Cell》 |2017年第1期|共3页
作者
Ott Christopher J.; Wu Catherine J.;
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作者单位

Harvard Med Sch Dana Farber Canc Inst Dept Med Oncol Boston MA 02115 USA;

Harvard Med Sch Dana Farber Canc Inst Dept Med Oncol Boston MA 02115 USA;

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正文语种 eng
中图分类肿瘤学;
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1. HDAC Inhibitors Finally Open Up: Chromatin Accessibility Signatures of CTCL [J] . Ott Christopher J., Wu Catherine J. Cancer Cell . 2017,第1期

机译：HDAC抑制剂最终开放：CTCL的染色质辅助性签名
2. BET inhibition markedly inhibits CTCL cell viability and is synergistically potentiated by BCL2 or HDAC inhibition [J] . Kim S., Cyrenne B., Lewis J., The Journal of investigative dermatology. . 2018,第5a19期

机译：BET抑制显着抑制CTCL细胞活力，并通过BCL2或HDAC抑制协同增强
3. Selective inhibition of HDAC6 sensitizes CTCL to PI3K inhibitors [J] . Bobrowicz Malgorzata, Stachura Joanna, Winiarska Magdalena European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR) . 2018,第期

机译：HDAC6的选择性抑制使CTCL敏化至PI3K抑制剂
4. Chemoproteomics profiling of HDAC inhibitors reveals HDAC complex dependent binding kinetics [C] . Isabelle Becher, Antje Dittmann, Mikhail M. Savitski, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2012

机译：HDAC抑制剂的化学蛋白质分析显示HDAC复合物依赖性结合动力学
5. The transcriptional regulation of the pro-survival protein Grp78 by activating transcription factors and chromatin-modifying enzymes: Its upregulation in response to HDAC-inhibitor treatment and the therapeutic consequences. [D] . Baumeister, Peter J. 2008

机译：通过激活转录因子和染色质修饰酶对生存蛋白Grp78的转录调控：响应HDAC抑制剂治疗及其治疗后果，其上调。
6. Chromatin accessibility landscape of cutaneous T cell lymphoma and dynamic response to HDAC inhibitors [O] . Kun Qu, Lisa C. Zaba, Ansuman T. Satpathy, -1

机译：皮肤T细胞淋巴瘤的染色质可及性及对HDAC抑制剂的动态响应
7. UpSET Recruits HDAC Complexes and Restricts Chromatin Accessibility and Acetylation at Promoter Regions [O] . Rincon-Arano Hector, Halow Jessica, Delrow Jeffrey J., 2012

机译：UpSET招募HDAC复合物并限制启动子区域的染色质可及性和乙酰化

HDAC Inhibitors Finally Open Up: Chromatin Accessibility Signatures of CTCL

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