Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis

Li Meng; Chiang Ying-Ling; Lyssiotis Costas A.; Teater Matthew R.; Hong Jun Young; Shen Hao; Wang Ling; Hu Jing; Jing Hui; Chen Zhengming; Jain Neeraj; Duy Cihangir; Mistry Sucharita J.; Cerchietti Leandro; Cross Justin R.; Cantley Lewis C.; Green Michael R.; Lin Hening; Melnick Ari M.

首页> 外文期刊>Cancer Cell >Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis

【24h】

Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis

机译：对SIRT3的非癌基因成瘾在淋巴瘤中起着关键作用

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Diffuse large B cell lymphomas (DLBCLs) are genetically heterogeneous and highly proliferative neoplasms derived from germinal center (GC) B cells. Here, we show that DLBCLs are dependent on mitochondrial lysine deacetylase SIRT3 for proliferation, survival, self-renewal, and tumor growth in vivo regardless of disease subtype and genetics. SIRT3 knockout attenuated B cell lymphomagenesis in VavP-Bcl2 mice without affecting normal GC formation. Mechanistically, SIRT3 depletion impaired glutamine flux to the TCA cycle via glutamate dehydrogenase and reduction in acetyl-CoA pools, which in turn induce autophagy and cell death. We developed a mitochondrial-targeted class I sirtuin inhibitor, YC8-02, which phenocopied the effects of SIRT3 depletion and killed DLBCL cells. SIRT3 is thus a metabolic non-oncogene addiction and therapeutic target for DLBCLs.

机译：弥漫性大B细胞淋巴瘤（DLBCLS）是衍生自发射生发中心（GC）B细胞的基因异质和高增殖的肿瘤。在这里，我们表明DLBCLS依赖于线粒体赖氨酸脱乙酰酶SIRT3以进行体内的增殖，存活，自我更新和肿瘤生长，无论疾病亚型和遗传学如何。 SIRT3敲除衰减B细胞淋巴瘤在VAVP-BCL2小鼠中而不影响正常的GC形成。机械地，SIRT3耗尽通过谷氨酸脱氢酶和减少乙酰-CoA池中的谷氨酰胺通量减少到TCA周期，这反过来诱导自噬和细胞死亡。我们开发了一种线粒体靶向I类Sirtuin抑制剂，YC8-02，其衰弱SIRT3耗竭和杀死DLBCL细胞的影响。因此，SIRT3是DLBCLS的代谢非癌基因成瘾和治疗靶标。

著录项

来源
《Cancer Cell》 |2019年第6期|共25页
作者
Li Meng; Chiang Ying-Ling; Lyssiotis Costas A.; Teater Matthew R.; Hong Jun Young; Shen Hao; Wang Ling; Hu Jing; Jing Hui; Chen Zhengming; Jain Neeraj; Duy Cihangir; Mistry Sucharita J.; Cerchietti Leandro; Cross Justin R.; Cantley Lewis C.; Green Michael R.; Lin Hening; Melnick Ari M.;
展开▼
作者单位

Weill Cornell Med Dept Med Div Hematol &

Med Oncol New York NY 10065 USA;

Cornell Univ Dept Chem &

Chem Biol Ithaca NY 14853 USA;

Univ Michigan Dept Mol &

Integrat Physiol Med Sch Ann Arbor MI 48109 USA;

Weill Cornell Med Dept Med Div Hematol &

Med Oncol New York NY 10065 USA;

Cornell Univ Dept Chem &

Chem Biol Ithaca NY 14853 USA;

Weill Cornell Med Dept Med Div Hematol &

Med Oncol New York NY 10065 USA;

Weill Cornell Med Dept Med Div Hematol &

Med Oncol New York NY 10065 USA;

Cornell Univ Dept Chem &

Chem Biol Ithaca NY 14853 USA;

Cornell Univ Dept Chem &

Chem Biol Ithaca NY 14853 USA;

Weill Cornell Med Div Biostat &

Epidemiol New York NY 10021 USA;

Univ Texas MD Anderson Canc Ctr Dept Lymphoma Myeloma Houston TX 77005 USA;

Weill Cornell Med Dept Med Div Hematol &

Med Oncol New York NY 10065 USA;

Weill Cornell Med Dept Med Div Hematol &

Med Oncol New York NY 10065 USA;

Weill Cornell Med Dept Med Div Hematol &

Med Oncol New York NY 10065 USA;

Mem Sloan Kettering Canc Ctr Canc Biol &

Genet Program New York NY 10065 USA;

Weill Cornell Med Meyer Canc Ctr New York NY 10065 USA;

Univ Texas MD Anderson Canc Ctr Dept Lymphoma Myeloma Houston TX 77005 USA;

Cornell Univ Dept Chem &

Chem Biol Ithaca NY 14853 USA;

Weill Cornell Med Dept Med Div Hematol &

Med Oncol New York NY 10065 USA;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类肿瘤学;
关键词

相似文献

外文文献
中文文献
专利

1. Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis [J] . Li Meng, Chiang Ying-Ling, Lyssiotis Costas A., Cancer Cell . 2019,第6期

机译：对SIRT3的非癌基因成瘾在淋巴瘤中起着关键作用
2. The role of sphingosine kinase 1 in cancer: oncogene or non-oncogene addiction? [J] . Vadas M, Xia P, McCaughan G Biochimica et Biophysica Acta. Molecular and cell biology of Lipids . 2008,第9期

机译：鞘氨醇激酶1在癌症中的作用：癌基因或非癌基因成瘾？
3. hsa-miR29b, a critical downstream target of non-canonical Wnt signaling, plays an anti-proliferative role in non-small cell lung cancer cells via targeting MDM2 expression hsa-miR29b, a critical downstream target of non-canonical Wnt signaling, plays an anti-proliferative role in non-small cell lung cancer cells via targeting MDM2 expression hsa-miR29b, a critical downstream target of non-canonical Wnt signaling, plays an anti-proliferative role in non-small cell lung cancer cells via targeting MDM2 expression [J] . Michael G. Edwards, Katherine Vandervest, John Arcaroli, Biology Open . 2013,第7期

机译：hsa-miR29b（非经典Wnt信号的关键下游靶标）通过靶向MDM2表达在非小细胞肺癌细胞中发挥抗增殖作用hsa-miR29b（非经典Wnt信号的关键下游靶标）通过靶向MDM2表达在非小细胞肺癌细胞中的抗增殖作用hsa-miR29b（非经典Wnt信号的关键下游靶点）通过靶向MDM2表达在非小细胞肺癌细胞中发挥抗增殖作用
4. OF MICE AND MICROGRAVITY: DOES SIRT3 PLAY A ROLE IN OXIDATIVE STRESS-INDUCED METABOLIC DYSFUNCTION [C] . Karen Jonscher ISS Research and Development Conference . 2013

机译：小鼠和微匍匐：SIRT3在氧化应激诱导的代谢功能障碍中发挥作用
5. An examination of massively multiplayer online role -playing games as a facilitator of Internet addiction [D] . Parsons, Jeffrey Michael 2005

机译：大型多人在线角色扮演游戏对网络成瘾的促进作用
6. The critical role that STAT3 plays in glioma-initiating cells: STAT3 addiction in glioma [O] . Debolina Ganguly, Meiyun Fan, Chuan He Yang, 2018

机译：STAT3在神经胶质瘤起始细胞中的关键作用：神经胶质瘤中的STAT3成瘾
7. Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis [O] . Meng Li, Ying-Ling Chiang, Costas A. Lyssiotis, 2019

机译：对SIRT3的非癌基因成瘾在淋巴瘤中起着关键作用

Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis

摘要

著录项

相似文献

相关主题

期刊订阅