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首页> 外文期刊>Balkan journal of medical genetics: BJMG >EFFECT OF THE Pro12Ala POLYMORPHISM OF THE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR gamma 2 GENE ON LIPID PROFILE AND ADIPOKINES LEVELS IN OBESE SUBJECTS
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EFFECT OF THE Pro12Ala POLYMORPHISM OF THE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR gamma 2 GENE ON LIPID PROFILE AND ADIPOKINES LEVELS IN OBESE SUBJECTS

机译：过氧化物酶体增殖物激活的受体γ2基因对肥胖曲线脂质曲线和脂质水平的影响

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摘要

Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a key regulator of metabolism, adipokines production and secretion. The aim of this study was to investigate the association between the PPAR gamma 2 gene Pro12Ala polymorphism in obesity in terms of body mass index (BMI), lipid parameters, homeostasis model assessment of insulin resistance (HOMA-IR), serum lipid, leptin, adiponectin, resistin and chemerin levels. The study included 160 obese and 140 non obese subjects. The Pro12Ala polymorphism was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Serum lipid, leptin, adiponectin, resistin and chemerin levels were measured. No association was found between the Pro12Ala polymorphism and BMI. Strikingly, in the study group, obese subjects with the AA genotype had significantly higher triglycerides (p = 0.046) and resistin (p 0.001) levels than those with the wild-type PP and heterozygous PA genotypes. Serum leptin and chemerin levels were significantly associated with Pro12Ala poymorphism in the obese and non obese groups (p 0.01). In the obese group, subjects with the homozygous AA genotype had significantly lower adiponectin (p = 0.010) activity than the PP genotype. Our results suggest that the PPAR gamma 2 gene Pro12Ala polymorphism has no direct association with obesity but does have significant influences on lipid profiles and adipokines levels.
机译：过氧化物体增殖剂活化受体γ（PPARγ）是代谢的关键调节因子，adipokines生产和分泌。本研究的目的是探讨PPARγ2基因Pro12Ala多态性在体重指数（BMI），血脂参数，胰岛素抵抗（HOMA-IR），血清脂，瘦素，瘦蛋白，脂联素，抵抗素和化学素水平。该研究包括160个肥胖和140个非肥胖科目。通过聚合酶链反应限制片段长度多态性（PCR-RFLP）测定Pro12Ala多态性。测量血清脂质，瘦素，脂联素，抵抗蛋白和化学素水平。 Pro12Ala多态性和BMI之间没有发现任何关联。引人注目的是，在研究组中，具有AA基因型的肥胖受试者具有显着高的甘油三酯（P = 0.046），并且抗蛋白（P <0.001）水平而不是野生型PP和杂合酶PA基因型。血清瘦素和培养素水平与肥胖和非肥胖基团的Pro12Ala Poymormism显着相关（P <0.01）。在肥胖组中，具有纯合AA基因型的受试者显着降低脂联素（P = 0.010）活性而不是PP基因型。我们的研究结果表明，PPARγ2基因Pro12Ala多态性与肥胖没有直接联合，但对脂质谱和脂肪因子水平产生显着影响。

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