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首页> 外文期刊>Clinical Biochemistry >Gender-specific effect of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma-2 gene on obesity risk and leptin levels in a Tunisian population.
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Gender-specific effect of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma-2 gene on obesity risk and leptin levels in a Tunisian population.

机译：过氧化物酶体增殖物激活的受体γ-2基因中Pro12Ala多态性对突尼斯人群中肥胖风险和瘦素水平的性别特异性影响。

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OBJECTIVES: This study was undertaken to investigate the impact of the Pro12Ala (rs1801282) polymorphism of the peroxisome proliferator-activated receptor gamma-2 (PPARgamma-2) gene on obesity or body mass index (BMI) and plasma leptin, insulin, adiponectin and lipid levels in a sample of the Tunisian population. DESIGN AND METHODS: The study included 387 obese patients and 288 control subjects. The Pro12Ala genotype was determined by polymerase chain reaction followed by a digestion with the restriction of endonuclease BstUI. RESULTS: In the whole population, there is no significant difference in genotype frequencies of the Pro12Ala polymorphism between obese patients and controls. However, separate analysis by gender revealed that obese men (but not women) had significantly higher frequency of Pro/Ala genotypes compared to controls (12.2% vs. 4.1%; chi(2)=6.76, p=0.009). In comparison to Pro/Pro homozygotes, Ala-allele bearers had a significantly higher risk of obesity [OR (95% CI)=3.26 (1.28-8.33)]. When obese subjects were stratified according to type 2 diabetes status, the association with obesity was only significant in obese non-diabetic patients [OR (95% CI)=3.74 (1.43-9.74), p=0.007]. Additionally, obese male patients carrying the Ala-allele had significantly higher body mass index (p=0.007) and plasma leptin levels (p=0.023) compared to those homozygous for Pro-allele. The significant effect of Pro12Ala polymorphism on plasma leptin levels disappeared after adjustment for age and BMI. CONCLUSION: The present study provides evidence that the Pro12Ala polymorphism of the PPARgamma-2 gene is associated with obesity in non-diabetic men from Tunisian origin.
机译：目的：本研究旨在研究过氧化物酶体增殖物激活受体γ-2（PPARgamma-2）基因的Pro12Ala（rs1801282）多态性对肥胖或体重指数（BMI）和血浆瘦素，胰岛素，脂联素和突尼斯人口样本中的血脂水平。设计与方法：该研究包括387位肥胖患者和288位对照对象。 Pro12Ala基因型是通过聚合酶链反应，然后在限制性内切酶BstUI的限制下消化来确定的。结果：在整个人群中，肥胖患者和对照组之间Pro12Ala多态性的基因型频率没有显着差异。但是，按性别进行的单独分析显示，肥胖男性（而非女性）的Pro / Ala基因型频率明显高于对照组（12.2％vs. 4.1％; chi（2）= 6.76，p = 0.009）。与Pro / Pro纯合子相比，Ala等位基因携带者肥胖的风险显着更高[OR（95％CI）= 3.26（1.28-8.33）]。根据2型糖尿病的状态对肥胖受试者进行分层时，肥胖与肥胖的关联仅在肥胖的非糖尿病患者中显着[OR（95％CI）= 3.74（1.43-9.74），p = 0.007]。此外，与纯等位基因纯合子相比，携带Ala等位基因的肥胖男性患者的体重指数（p = 0.007）和血浆瘦素水平（p = 0.023）明显更高。调整年龄和BMI后，Pro12Ala多态性对血浆瘦素水平的显着影响消失了。结论：本研究提供了证据，证明PPARgamma-2基因的Pro12Ala多态性与来自突尼斯的非糖尿病男性肥胖有关。

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