Waltonitone induces human hepatocellular carcinoma cells apoptosis in vitro and in vivo.

Zhang Z; Wang S; Qiu H; Duan C; Ding K; Wang Z

首页> 外文期刊>Cancer letters >Waltonitone induces human hepatocellular carcinoma cells apoptosis in vitro and in vivo.

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Waltonitone induces human hepatocellular carcinoma cells apoptosis in vitro and in vivo.

机译：Waltonitone在体外和体内诱导人类肝细胞癌细胞凋亡。

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Waltonitone, a new ursane-type pentacyclic triterpene isolated from Gentian waltonii Burkill significantly inhibited human hepatocellular carcinoma BEL-7402 cells growth. Apoptosis induced by waltonitone was characterized by AO/EB staining and flow cytometric analysis. Apoptosis microarray assay results showed BCL-2 family genes might especially play an important role in waltonitone-induced apoptosis. RT-PCR and Western blotting analysis showed that waltonitone could induce tumor cell apoptosis via both death receptor and mitochondria pathways. Meanwhile, the inhibitory effect of waltonitone was examined in vivo using BEL-7402 tumor cells xenografted into athymic mice model. In summary, these studies demonstrated that waltonitone might inhibit hepatocellular carcinoma cells growth and induce apoptosis in vitro and in vivo.

机译：从龙胆沃尔顿氏菌布基尔隔离的新的熊烷型五环三萜段，显着抑制人肝细胞癌Bel-7402细胞生长。 Waltonitone诱导的凋亡的特征在于AO / EB染色和流式细胞术分析。细胞凋亡微阵列测定结果显示Bcl-2家族基因可能尤其在Waltonitone诱导的细胞凋亡中起重要作用。 RT-PCR和Western印迹分析表明，Waltonitone可以通过死亡受体和线粒体途径诱导肿瘤细胞凋亡。同时，使用Bel-7402肿瘤细胞异种移植到无胸腺小鼠模型中，在体内检测Waltonitone的抑制作用。总之，这些研究表明，Waltonitone可能会抑制肝细胞癌细胞生长并在体外和体内诱导细胞凋亡。

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《Cancer letters》 |2010年第2期|共9页
作者
Zhang Z; Wang S; Qiu H; Duan C; Ding K; Wang Z;
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Key Laboratory of Standardization of Chinese Medicines of Ministry of Education Institute of;

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正文语种 eng
中图分类肿瘤学;
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1. Waltonitone induces human hepatocellular carcinoma cells apoptosis in vitro and in vivo. [J] . Zhang Z, Wang S, Qiu H, Cancer letters . 2010,第2期

机译：Waltonitone在体外和体内诱导人类肝细胞癌细胞凋亡。
2. Waltonitone induces human hepatocellular carcinoma cells apoptosis in vitro and in vivo. [J] . Zhang Z, Wang S, Qiu H, Cancer letters . 2009,第2期

机译：沃尔托尼酮在体外和体内均可诱导人肝癌细胞凋亡。
3. Urocanic acid-modified chitosan-mediated p53 gene delivery inducing apoptosis of human hepatocellular carcinoma cell line HepG2 is involved in its antitumor effect in vitro and in vivo. [J] . Wang W, Yao J, Zhou JP, Biochemical and Biophysical Research Communications . 2008,第2期

机译：尿烷酸修饰的壳聚糖介导的p53基因传递诱导人肝癌细胞HepG2凋亡涉及其在体内和体外的抗肿瘤作用。
4. The effect and mechanism of Apoptosis induced by Desacetylcinobufotalin (DEBF) in human hepatocellular carcinoma HepG2 cells [C] . Xu Chao, Lin Dang, Minhui Wei International Conference on Advanced Design and Manufacturing Engineering . 2013

机译：Desacetylcinobufotalin（Debf）在人肝细胞癌HepG2细胞中诱导细胞凋亡的影响及机制
5. Cannabinol Inhibits Proliferation and Induces Cell Cycle Arrest and Apoptosis in Glioblastoma, Hepatocellular Carcinoma and Breast Cancer Cells [D] . Zhong, Nuanying. 2020

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6. The Novel Nature Microtubule Inhibitor Ivalin Induces G2/M Arrest and Apoptosis in Human Hepatocellular Carcinoma SMMC-7721 Cells In Vitro [O] . Fangyuan Liu, Shiqi Lin, Caiyun Zhang, 2019

机译：新型自然微管抑制剂伊瓦林诱导人肝癌细胞SMMC-7721细胞的G2 / M逮捕和凋亡。
7. Salinomycin inhibits proliferation and induces apoptosis of human hepatocellular carcinoma cells in vitro and in vivo. [O] . Fan Wang, Lei He, Wei-Qi Dai, 2012

机译：沙利霉素在体外和体内抑制人肝细胞癌细胞的增殖并诱导其凋亡。

Waltonitone induces human hepatocellular carcinoma cells apoptosis in vitro and in vivo.

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