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首页> 外文期刊>Cancer prevention research. >A Randomized Controlled Trial Testing Provision of Fecal and Blood Test Options on Participation for Colorectal Cancer Screening
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A Randomized Controlled Trial Testing Provision of Fecal and Blood Test Options on Participation for Colorectal Cancer Screening

机译：随机对照试验在参与结肠直肠癌筛查时提供粪便和血液测试选择

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Suboptimal participation is commonly observed in colorectal cancer screening programs utilizing fecal tests. This randomized controlled trial tested whether the offer of a blood test as either a "rescue" strategy for fecal test nonparticipants or an upfront choice, could improve participation. A total of 1,800 people (50-74 years) were randomized to control, rescue, or choice groups (n = 600/group). All were mailed a fecal immunochemical test (FIT, OC-Sensor, liken Chemical Company) and a survey assessing awareness of the screening tests. The rescue group was offered a blood test 12 weeks after FIT nonparticipation. The choice group was given the opportunity to choose to do a blood test (Colvera, Clinical Genomics) instead of FIT at baseline. Participation with any test after 24 weeks was not significantly different between groups (control, 37.8%; rescue, 36.9%; choice, 33.8%; P> 0.05). When the rescue strategy was offered after 12 weeks, an additional 6.5% participated with the blood test, which was greater than the blood test participation when offered as an upfront choice (1.5%; P < 0.001). Awareness of the tests was greater for FIT than for blood (96.2% vs. 23.1%; P < 0.0001). In a population familiar with FIT screening, provision of a blood test either as a rescue of FIT nonparticipants or as an upfront choice did not increase overall participation. This might reflect a lack of awareness of the blood test for screening compared with FIT.
机译：在利用粪便测试的结肠直肠癌筛查计划中通常观察到次优参与。这种随机对照试验测试了血液测试的报价是否为粪便测试非遗传物或前期选择的“救援”策略可以改善参与。共有1,800人（50-74岁）被随机控制，救援或选择群（n = 600 /组）。所有全部邮寄了一种粪便免疫化学测试（FIT，OC-SENSOR，LICK COMPORAL COMPANY）以及评估筛查测试的认识。救援组在适合非分支后12周内提供血液试验。选择组有机会选择进行血液测试（COLVERA，临床基因组学）而不是适合基线。在24周后参加任何测试在组之间没有显着差异（对照，37.8％;救援，36.9％;选择，33.8％; p> 0.05）。当12周后提供救援策略时，额外的6.5％参加了血液试验，该试验大于血液测试参与，当为前期选择提供（1.5％; P <0.001）。对测试的认识比血液更大（96.2％vs.23.1％; P <0.0001）。在熟悉拟合筛查的人群中，提供血液测试作为适合的非公分体或作为前期选择的救援并未增加整体参与。与合适相比，这可能反映了对筛查血液检测的认识。

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