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首页> 外文期刊>Cardiology >Osteocardiology: Defining the Go/No-Go Time Point for Therapy
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Osteocardiology: Defining the Go/No-Go Time Point for Therapy

机译：骨内膜学：定义治疗的GO / NO-GO时间点

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Recent epidemiological studies have revealed that the risk factors associated with coronary artery calcification (CAC), including male gender, smoking, hypertension, and elevated serum cholesterol, are similar to the risk factors associated with the development of calcific aortic valve disease (CAVD). The results of the experimental and clinical studies demonstrate that traditional risk factors initiate early atherosclerosis which over time differentiates to form bone in the heart causing clinical CAC and CAVD. Understanding the cellular mechanisms of cardiovascular calcification, the end-stage process of the atherosclerosis will help define the specific time point to modify this cellular process of bone formation in the heart termed osteocardiology. This time point between subclinical atherosclerosis and clinical calcification is the go/no-go time point, or the point of no return with severe clinical calcification in the heart. This review will summarize the development of bone formation in the heart termed osteocardiology, to define the go/no-go time point for therapy initiation to slow the progression of cardiovascular calcification.
机译：最近的流行病学研究表明，与冠状动脉钙化（CAC）相关的风险因素，包括男性性别，吸烟，高血压和血清胆固醇，与钙化主动脉瓣病（CAVD）的发展相关的危险因素类似。实验和临床研究的结果表明，传统的风险因素引发早期动脉粥样硬化，随着时间的推移，在导致临床CAC和CAVD的心脏中形成骨骼。理解心血管钙化的细胞机制，动脉粥样硬化的终级过程将有助于定义特定的时间点，以改变心脏所谓的骨动脉学中骨形成的细胞过程。亚临床动脉粥样硬化和临床钙化之间的这一时间点是GO / NO-GO时间点，或心脏中严重的临床钙化的返回点。本综述将总结心脏被称为骨膜的骨形成的发展，以定义治疗启动的GO / NO-GO时间点，以减缓心血管钙化进展。

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