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首页> 外文期刊>Cardiology >Sex-Related Differences in the Impact of Systemic Hypertension on Left Ventricular Remodeling in Patients with Hypertrophic Obstructive Cardiomyopathy
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Sex-Related Differences in the Impact of Systemic Hypertension on Left Ventricular Remodeling in Patients with Hypertrophic Obstructive Cardiomyopathy

机译：系统高血压对肥厚性阻塞性心肌病患者左心室重塑的影响的性与相关差异

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Background: The clinical condition of hypertrophic obstructive cardiomyopathy (HOCM) and concomitant systemic hypertension is growing more and more prevalent, and it brings about a challenging diagnostic and therapeutic dilemma. However, whether systemic hypertension has an impact on HOCM, and whether sex-related differences exist in this impact, remains unclear. Methods: A total of 453 HOCM patients (age 48.7 +/- 12.8 years, 252 [55.6%] males) were recruited in this study. There were 150 patients (33.1%, 81 males and 69 females) with a history of controlled systemic hypertension. Cardiac magnetic resonance (CMR) imaging was performed in all patients. Left ventricular (LV) remodeling index (LVRI) was determined by CMR. LVRI >1.3 g/mL was defined as pathological LV remodeling. Results: Men had significantly greater LVRI (1.40 +/- 0.54 vs. 1.15 +/- 0.38 g/mL, p 1.3 g/mL (p = 0.002), compared with women. The incidence of syncope and 5-year sudden cardiac death risk score were significantly lower in HOCM with hypertension than those without hypertension. LVRI (p = 0.003) and LVRI >1.3 g/mL (p = 0.007) were significantly smaller in males with hypertension, but not in females with hypertension. However, log cardiac troponin I and log N-terminal pro-B-type natriuretic peptide were positively correlated with LVRI in men and women. On multivariable logistic analysis, hypertension (OR 0.172, 95% CI 0.056-0.528, p = 0.002) remained an independent determinant of pathological LV remodeling in males, whereas not in females. Conclusions: There were significant sex differences in the impact of systemic hypertension on LV remodeling in patients with HOCM. Controlled systemic hypertension may contribute to improving LV remodeling in male patients with HOCM, but not in females.
机译：背景：肥厚性阻塞性心肌病（HOCM）和伴随的全身高血压的临床条件越来越普遍，它带来了挑战性的诊断和治疗困境。然而，系统性高血压是否对肺部产生影响，以及这种影响是否存在与性有关的差异，仍不清楚。方法：共有453名患有453名患者（年龄48.7 +/- 12.8岁，在本研究中招募了252 [55.6％]男性）。有150名患者（33.1％，81名男性和69名女性），具有受控全身高血压的历史。在所有患者中进行心脏磁共振（CMR）成像。通过CMR测定左心室（LV）重塑指数（LVRI）。 Lvri> 1.3 g / ml被定义为病理LV重塑。结果：男性具有明显的LVRI（1.40 +/- 0.54与1.15 +/- 0.38g / ml，p 1.3 g / ml（p = 0.002），与女性相比。晕厥和5年突发的心脏死亡率HOCM的风险评分比没有高血压的高血压显着降低。LVRI（P = 0.003）和LVRI> 1.3g / ml（p = 0.007）在具有高血压的男性中显着较小，但没有高血压的女性。但是，日志心肌肌钙蛋白I和Log N-末端Pro-B型利钠肽与男性和女性的LVRI正相关。在多变量物流分析中，高血压（或0.172,95％CI 0.528，P = 0.002）仍然是一个独立的决定因素病理LV在雄性中改造的影响在女性s。

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