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首页> 外文期刊>Acta ophthalmologica >Exogenous oestrogen exposure, female reproductive factors and the long-term incidence of cataract: the Blue Mountains Eye Study.
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Exogenous oestrogen exposure, female reproductive factors and the long-term incidence of cataract: the Blue Mountains Eye Study.

机译：外源性雌激素暴露，女性生殖因子和白内障的长期发生：《蓝山眼》研究。

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PURPOSE: To assess the association between exogenous oestrogen exposure, female reproductive factors and the long-term incidence of cataract. METHODS: People aged 49+ years living in a defined geographic region were invited to participate in this prospective population-based survey. Of 2072 women (83% of those eligible) who were examined during 1992-1994 at baseline, around 75% of survivors were re-examined at 5- and 10-year follow-up visits. Lens photographs were assessed using the Wisconsin Cataract Grading System by masked graders. An interviewer-administered questionnaire was used at each visit to collect information on female reproductive factors and the use of the oral contraceptive pill and postmenopausal hormone replacement therapy. RESULTS: After adjusting for age, smoking, socioeconomic status, steroid use, hypertension and diabetes, ever having used the oral contraceptive pill had a mild protective effect against incident cortical cataract (odds ratio 0.70, 95% confidence interval 0.50-0.98). However, hormone replacement therapy, age at menarche, age at menopause, duration of exposure to endogenous oestrogen, parity and type of menopause were not found to have significant associations with the incidence of any type of cataract or cataract surgery. CONCLUSION: Apart from a weak protective association of oral contraceptive pill use and the development of cortical cataract, we found no significant longitudinal associations between exogenous oestrogen exposure, female reproductive factors and the long-term incidence of cataract in this older population-based cohort.
机译：目的：评估外源性雌激素暴露，女性生殖因素与白内障的长期发生率之间的关系。方法：邀请49岁以上，居住在指定地理区域的人们参加这项基于人口的前瞻性调查。在1992-1994年期间接受基线检查的2072名妇女（占合格妇女的83％）中，约有75％的幸存者在5年和10年的随访中接受了重新检查。蒙面分级员使用威斯康星州白内障分级系统评估镜头照片。每次访视时使用访调员管理的调查表收集有关女性生殖因素以及口服避孕药和绝经后激素替代疗法的信息。结果：在调整了年龄，吸烟，社会经济地位，类固醇使用，高血压和糖尿病后，曾经使用口服避孕药对皮层性白内障有轻度的保护作用（几率0.70，95％置信区间0.50-0.98）。然而，未发现激素替代疗法，初潮年龄，绝经年龄，内源性雌激素暴露持续时间，产妇的绝经和类型与任何类型的白内障或白内障手​​术的发生率均无显着相关性。结论：除了口服避孕药的使用与皮肤白内障的发展有较弱的保护性关联外，我们在这个老年人口人群中未发现外源性雌激素暴露，女性生殖因子与白内障的长期发生之间存在明显的纵向关联。

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