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An Estimation of the Worldwide Epidemiologic Burden of Physical Inactivity-Related Ischemic Heart Disease

机译：估计全球流行性相关缺血性心脏病的流行病学负担

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Purpose Although physical inactivity (PI) is universally considered a major risk factor for cardiovascular disorders, no previous study has investigated its putative contribution on the societal and healthcare burden of ischemic heart disease (IHD). Therefore, we aimed to provide an objective assessment of the worldwide epidemiology of PI-related IHD. Methods An electronic search was performed in the Global Health Data Exchange (GHDx) registry, a large database of health-related data, for assessing the worldwide epidemiology of PI-related IHD. Results The current burden of PI-related disability-adjusted life years (DALYs) and deaths caused by IHD is 9.1% (15.42 out of 170.27 million DALYs) and 9.9% (5.46 out of 55.14 million deaths), respectively. Women have a similar to 14% higher risk of both PI-related DALYs and mortality. The impact of PI on IHD remains stable around 7% up to the middle age, then gradually increases in parallel with aging, up to over 11%. A similar to 20% higher risk of PI-related DALYs and mortality caused by IHD can be found in countries with middle-to-high socio-demographic index (SDI) compared with countries with lower SDIs. In multivariable analysis, PI-related DALYs and mortality caused by IHD were significantly predicted by female sex, advanced age, and higher SDI. Conclusions The results of our analysis suggest that reinforced efforts shall be prioritized and scaled up for broadening and ameliorating the application of physical activity recommendations in populations more vulnerable to the risk of PI-related IHD.
机译：目的虽然物理不活动（PI）普遍认为心血管障碍的主要危险因素，但之前没有研究其对缺血性心脏病（IHD）的社会和医疗保健负担的推定贡献。因此，我们旨在为PI相关IHD的全球流行病学提供客观评估。方法在全球健康数据交换（GHDX）注册表中进行电子搜索，用于评估PI相关IHD的全球流行病学的大型健康相关数据数据库。结果IHD引起的PI相关残疾调整后的生命年（DALYS）和死亡的目前的负担分别为9.1％（超过17027万达尔多斯的15.42），分别为9.9％（5514万人死亡）。女性与PI相关的DALYS和死亡率的风险较高了14％。 PI对IHD的影响仍然稳定在7％的稳定上年，然后随着老化逐渐增加，高达11％以上。类似于20％的PI相关DALYS风险和由IHD引起的死亡率可以在具有下高级社会人口指数（SDI）的国家中找到，与具有较低SDIS的国家相比。在多变量分析中，女性性别，晚期和高等SDI显着预测了与IHD引起的PI相关的DALYS和死亡率。结论我们的分析结果表明，加强努力应优先考虑并扩大扩大和改善人口中的身体活动建议在群体中的应用危害与PI相关的IHD风险的应用。

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