IL-17 is elevated in cerebrospinal fluids in bacterial meningitis in children.

Asano T; Ichiki K; Koizumi S; Kaizu K; Hatori T; Fujino O; Mashiko K; Sakamoto Y; Miyasho T; Fukunaga Y

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IL-17 is elevated in cerebrospinal fluids in bacterial meningitis in children.

机译：儿童细菌性脑膜炎的脑脊液中IL-17升高。

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Bacterial meningitis has a poor prognosis and neurologic complications. The present study aimed to investigate the cytokine/chemokine network in cerebrospinal fluid (CSF) from children with bacterial meningitis and aseptic meningitis. Interleukin (IL)-1beta, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12, IL-13, IL-17, interferon-gamma, tumor necrosis factor-alpha, granulocyte colony-stimulating factor, granulocyte monocyte colony-stimulating factor, monocyte chemoattractant protein-1 and macrophage inflammatory protein-1beta, were measured simultaneously in CSF supernatants. We found that, IL-17 was significantly elevated in CSF with bacterial meningitis. We believe that IL-17 plays a key role in neutrophil infiltration into CSF and neuronal protection in bacterial meningitis.

机译：细菌性脑膜炎预后差，神经系统并发症多。本研究旨在调查细菌性脑膜炎和无菌性脑膜炎患儿脑脊液（CSF）中的细胞因子/趋化因子网络。白介素（IL）-1beta，IL-2，IL-4，IL-5，IL-6，IL-7，IL-8，IL-10，IL-12，IL-13，IL-17，γ干扰素同时，在脑脊液上清液中同时测定肿瘤坏死因子-α，粒细胞集落刺激因子，粒细胞单核细胞集落刺激因子，单核细胞趋化蛋白-1和巨噬细胞炎性蛋白-1β。我们发现，在细菌性脑膜炎的脑脊液中IL-17明显升高。我们相信IL-17在嗜中性粒细胞浸润CSF和细菌性脑膜炎的神经元保护中起着关键作用。

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《Cytokine》 |2010年第1期|共6页
作者
Asano T; Ichiki K; Koizumi S; Kaizu K; Hatori T; Fujino O; Mashiko K; Sakamoto Y; Miyasho T; Fukunaga Y;
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正文语种 eng
中图分类细胞生物学;
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1. IL-17 is elevated in cerebrospinal fluids in bacterial meningitis in children. [J] . Asano T, Ichiki K, Koizumi S, Cytokine . 2010,第1期

机译：儿童细菌性脑膜炎的脑脊液中IL-17升高。
2. An evaluation of lactic acid, protein and glucose in cerebrospinal fluid for early diagnosis of bacterial meningitis in children. A simple and economic method. [J] . Bousquet José Ramón, Cáceres Alfonso, Luces Oswaldo, VITAE : Academia Biomédica Digital . 2009,第37期

机译：评估脑脊液中的乳酸，蛋白质和葡萄糖对儿童细菌性脑膜炎的早期诊断。一种简单而经济的方法。
3. Gelatinase B (matrix metalloproteinase (MMP)-9) and collagenases (MMP-8/-13) are upregulated in cerebrospinal fluid during aseptic and bacterial meningitis in children. [J] . Lindberg RL, Sorsa T, Tervahartiala T, Neuropathology and applied neurobiology . 2006,第3期

机译：儿童无菌性和细菌性脑膜炎期间，脑脊液中的明胶酶B（基质金属蛋白酶（MMP）-9）和胶原酶（MMP-8 / -13）上调。
4. Lens-free microscopy of cerebrospinal fluid for the laboratory diagnosis of meningitis [C] . Robin Delacroix, Sophie Nhu An Morel, Lionel Herve, Conference on frontiers in biological detection: from nanosensors to systems . 2018

机译：脑脊液无镜显微镜检查对脑膜炎的实验室诊断
5. Towards multidimensional separations of cerebrospinal fluid proteins in microfluidic devices. [D] . Li, Chen. 2005

机译：迈向微流体装置中脑脊液蛋白质的多维分离。
6. Correlation of cerebrospinal fluid endotoxinlike activity with clinical and laboratory variables in gram-negative bacterial meningitis in children. [O] . T L Dwelle, L M Dunkle, L Blair 1987

机译：儿童革兰氏阴性细菌性脑膜炎脑脊液内毒素样活性与临床和实验室变量的相关性。
7. Cerebrospinal Fluid (CSF) Lactic Acid Levels: a Rapid and Reliable Way To Differentiate Viral from Bacterial Meningitis or Concurrent Viral/Bacterial Meningitis [O] . Cunha, Burke A. 2011

机译：脑脊液（CSF）乳酸水平：一种快速可靠的方法来区分病毒与细菌性脑膜炎或并发病毒/细菌性脑膜炎
8. Prognostic Value of Cerebrospinal Fluid Protein Content and Leukocyte Count inInfants and Childhood Bacterial Meningitis. (Reannouncement with New Availability Information) [R] . Shaaban, S. Y., Girgis, N. I., Mansour, M. M., 1991

机译：脑脊液蛋白含量和白细胞计数在婴儿和儿童细菌性脑膜炎中的预后价值。（重新公布新的可用性信息）

IL-17 is elevated in cerebrospinal fluids in bacterial meningitis in children.

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