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首页> 外文期刊>Cell Host & Microbe >BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity
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BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity

机译：BCG疫苗接种通过诱导与培训的免疫相关的细胞因子诱导人类的实验病毒感染

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摘要

The tuberculosis vaccine bacillus Calmette-Gue 'rin (BCG) has heterologous beneficial effects against non-related infections. The basis of these effects has been poorly explored in humans. In a randomized placebo-controlled human challenge study, wefound that BCG vaccination induced genome-wide epigenetic reprograming of monocytes and protected against experimental infection with an attenuated yellow fever virus vaccine strain. Epigenetic reprogramming was accompanied by functional changes indicative of trained immunity. Reduction of viremia was highly correlated with the upregulation of IL-1b, a heterologous cytokine associated with the induction of trained immunity, but not with the specific IFNg response. The importance of IL-1b for the induction of trained immunity was validated through genetic, epigenetic, and immunological studies. In conclusion, BCG induces epigenetic reprogramming in human monocytes in vivo, followed by functional reprogramming and protection against non-related viral infections, with a key role for IL-1b as a mediator of trained immunity responses.
机译：结核病疫苗Bacillus upbette-Gue'Rin（BCG）对非相关感染具有异源有益的影响。这些效果的基础在人类中探讨了很差。在随机安慰剂控制的人攻击研究中，WEFOUND促进BCG疫苗接种诱导的单核细胞基因组的表观遗传重新编程，并受到减毒的黄热病病毒疫苗菌株的实验感染。表观遗传重编程伴随着训练有素的抗扰度的功能变化。病毒血症的减少与IL-1B的上调，与诱导培训的免疫感染的异源细胞因子高度相关，但不具有特定的IFNG反应。通过遗传，表观遗传和免疫研究验证了IL-1B对培训的免疫感应的重要性。总之，BCG诱导体内人核细胞中的表观遗传重编程，其次是功能重编程和免受无关病毒感染的保护，对IL-1B作为培训的免疫反应的介质具有关键作用。

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  • 来源
    《Cell Host & Microbe》 |2018年第1期|共17页
  • 作者

    Arts Rob J. W.; Moorlag Simone J. C. F. M.; Novakovic Boris; Li Yang; Wang Shuang-Yin; Oosting Marije; Kumar Vinod; Xavier Ramnik J.; Wijmenga Cisca; Joosten Leo A. B.; Reusken Chantal B. E. M.; Benn Christine S.; Aaby Peter; Koopmans Marion P.; Stunnenberg Hendrik G.; van Crevel Reinout; Netea Mihai G.;

  • 作者单位

    Radboud Univ Nijmegen Dept Internal Med Med Ctr Nijmegen Netherlands;

    Radboud Univ Nijmegen Dept Internal Med Med Ctr Nijmegen Netherlands;

    Radboud Univ Nijmegen Dept Mol Biol Nijmegen Netherlands;

    Univ Groningen Univ Med Ctr Groningen Dept Genet Groningen Netherlands;

    Radboud Univ Nijmegen Dept Internal Med Med Ctr Nijmegen Netherlands;

    Radboud Univ Nijmegen Dept Internal Med Med Ctr Nijmegen Netherlands;

    Univ Groningen Univ Med Ctr Groningen Dept Genet Groningen Netherlands;

    Harvard Sch Med Massachusetts Gen Hosp Ctr Computat &

    Integrat Biol Boston MA USA;

    Univ Groningen Univ Med Ctr Groningen Dept Genet Groningen Netherlands;

    Radboud Univ Nijmegen Dept Internal Med Med Ctr Nijmegen Netherlands;

    Erasmus Univ Dept Virosci WHO Collaborating Ctr Arboviruses &

    Viral Hemorrh Med Ctr Rotterdam Netherlands;

    Statens Serum Inst Bandim Hlth Project Res Ctr Vitamins &

    Vaccines CVIVA Copenhagen Denmark;

    Statens Serum Inst Bandim Hlth Project Res Ctr Vitamins &

    Vaccines CVIVA Copenhagen Denmark;

    Erasmus Univ Dept Virosci WHO Collaborating Ctr Arboviruses &

    Viral Hemorrh Med Ctr Rotterdam Netherlands;

    Radboud Univ Nijmegen Dept Mol Biol Nijmegen Netherlands;

    Radboud Univ Nijmegen Dept Internal Med Med Ctr Nijmegen Netherlands;

    Radboud Univ Nijmegen Dept Internal Med Med Ctr Nijmegen Netherlands;

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  • 正文语种 eng
  • 中图分类 普通生物学;
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