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首页> 外文期刊>Cell metabolism >Preclinical Models for Studying NASH-Driven HCC: How Useful Are They?
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Preclinical Models for Studying NASH-Driven HCC: How Useful Are They?

机译：研究NASH驱动HCC的临床前模型：它们有多有用？

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Hepatocellular carcinoma (HCC) is one of the most fatal and fastest-growing cancers. Recently, non-alcoholic steatohepatitis (NASH) has been recognized as a major HCC catalyst. However, it is difficult to decipher the molecular mechanisms underlying the pathogenesis of NASH and understand how it progresses to HCC by studying humans. Progress in this field depends on the availability of reliable preclinical models amenable to genetic and functional analyses and exhibiting robust NASH-to-HCC progression. Although numerous mouse models of NASH have been described, many do not faithfully mimic the human disease and few reliably progress to HCC. Here, we review current literature on the molecular etiology of NASH-related HCC and critically evaluate existing mouse models and their suitability for studying this malignancy. We also compare human transcriptomic and histopathological profiles with data from MUP-uPA mice, a reliable model of NASH-driven HCC that has been useful for evaluation of HCC-targeting immuno-therapies.
机译：肝细胞癌（HCC）是最致命和生长最快的癌症之一。最近，非酒精脱脂性炎（NASH）被认为是主要的HCC催化剂。然而，难以破译纳什发病机制的分子机制，并了解如何通过研究人类对HCC进行。该领域的进步取决于可靠的临床前模型可用于遗传和功能分析，并表现出强大的纳什对HCC进展。虽然已经描述了许多纳什的小鼠模型，但许多人不忠实地模仿人类疾病，并且很少可靠地进入HCC。在这里，我们审查了现有的纳什相关HCC分子病因的文献，并重要地评估了现有的小鼠模型及其对研究这种恶性肿瘤的适用性。我们还将人体转录组和组织病理学分布与来自MUP-UPA小鼠的数据进行比较，是一种可靠的纳什驱动的HCC模型，这对于评估HCC靶向免疫疗法而言已经有用。

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