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首页> 外文期刊>Cell metabolism >Cell-Intrinsic Glycogen Metabolism Supports Early Glycolytic Reprogramming Required for Dendritic Cell Immune Responses
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Cell-Intrinsic Glycogen Metabolism Supports Early Glycolytic Reprogramming Required for Dendritic Cell Immune Responses

机译：细胞内糖原代谢支持树突细胞免疫应答所需的早期糖酵母重编程

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摘要

Dendritic cell (DC) activation by Toll-like receptor (TLR) agonists causes rapid glycolytic reprogramming that is required to meet the metabolic demands of their immune activation. Recent efforts in the field have identified an important role for extracellular glucose sourcing to support DC activation. However, the contributions of intracellular glucose stores to these processes have not been well characterized. We demonstrate that DCs possess intracellular glycogen stores and that cell-intrinsic glycogen metabolism supports the early effector functions of TLR-activated DCs. Inhibition of glycogenolysis significantly attenuates TLR-mediated DC maturation and impairs their ability to initiate lymphocyte activation. We further report that DCs exhibit functional compartmentalization of glucose-and glycogen-derived carbons, where these substrates preferentially contribute to distinct metabolic pathways. This work provides novel insights into nutrient homeostasis in DCs, demonstrating that differential utilization of glycogen and glucose metabolism regulates their optimal immune function.
机译：通过Toll样受体（TLR）激动剂的树突状细胞（DC）激活导致快速糖糖重编程，需要满足其免疫激活的代谢需求。最近在该领域的努力已经确定了细胞外葡萄糖采购以支持DC活化的重要作用。然而，细胞内葡萄糖储存对这些过程的贡献并未很好地表征。我们证明DCS具有细胞内糖原储存，并且细胞内在糖原代谢支持TLR活化DC的早期效应功能。抑制血糖生成显着衰减TLR介导的直流成熟，并损害它们引发淋巴细胞活化的能力。我们进一步报告，DCS表现出葡萄糖和糖原衍生的碳的功能性分区化，其中这些基材优先有助于不同的代谢途径。这项工作为DCS中的营养性稳态提供了新颖的洞察力，表明糖原和葡萄糖代谢的差异利用调节其最佳免疫功能。

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  • 来源
    《Cell metabolism》 |2017年第3期|共15页
  • 作者

    Thwe Phyu M.; Pelgrom Leonard; Cooper Rachel; Beauchamp Saritha; Reisz Julie A.; DAlessandro Angelo; Everts Bart; Amiel Eyal;

  • 作者单位

    Univ Vermont Cell Mol &

    Biomed Sci Program Burlington VT 05405 USA;

    Leiden Univ Med Ctr Dept Parasitol NL-2333 ZA Leiden Netherlands;

    Univ Vermont Coll Nursing &

    Hlth Sci Dept Med Lab &

    Radiat Sci Burlington VT 05405 USA;

    Univ Vermont Coll Nursing &

    Hlth Sci Dept Med Lab &

    Radiat Sci Burlington VT 05405 USA;

    Univ Colorado Denver Dept Biochem &

    Mol Genet Anschutz Med Campus Aurora CO 80045 USA;

    Univ Colorado Denver Dept Biochem &

    Mol Genet Anschutz Med Campus Aurora CO 80045 USA;

    Leiden Univ Med Ctr Dept Parasitol NL-2333 ZA Leiden Netherlands;

    Univ Vermont Cell Mol &

    Biomed Sci Program Burlington VT 05405 USA;

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  • 正文语种 eng
  • 中图分类 内分泌腺疾病及代谢病;
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