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首页> 外文期刊>Cell metabolism >Actomyosin-Mediated Tension Orchestrates Uncoupled Respiration in Adipose Tissues
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Actomyosin-Mediated Tension Orchestrates Uncoupled Respiration in Adipose Tissues

机译：Actomyosin介导的张力促进脂肪组织中的未耦合呼吸

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摘要

The activation of brown/beige adipose tissue (BAT) metabolism and the induction of uncoupling protein 1 (UCP1) expression are essential for BAT-based strategies to improve metabolic homeostasis. Here, we demonstrate that BAT utilizes actomyosin machinery to generate tensional responses following adrenergic stimulation, similar to muscle tissues. The activation of actomyosin mechanics is critical for the acute induction of oxidative metabolism and uncoupled respiration in UCP1(+) adipocytes. Moreover, we show that actomyosin-mediated elasticity regulates the thermogenic capacity of adipocytes via the mechanosensitive transcriptional co-activators YAP and TAZ, which are indispensable for normal BAT function. These biomechanical signaling mechanisms may inform future strategies to promote the expansion and activation of brown/beige adipocytes.
机译：棕色/米色脂肪组织（BAT）代谢的激活和解耦蛋白1（UCP1）表达的诱导对于基于BAT的策略来改善代谢稳态，是必不可少的。 在这里，我们证明BAT利用Actomyosin机械在肾上腺素能刺激后产生张力响应，类似于肌肉组织。 Actomyosin Mechence的激活对于UCP1（+）脂肪细胞中氧化代谢和未耦合呼吸的急性诱导至关重要。 此外，我们表明，术曲调介导的弹性通过机械敏感性转录共振活性剂YAP和TAZ调节脂肪细胞的热容量，这对于正常蝙蝠功能是必不可少的。 这些生物力学信号传导机制可能会通知未来的策略，以促进棕色/米色脂肪细胞的扩张和激活。

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  • 来源
    《Cell metabolism》 |2018年第3期|共18页
  • 作者

    Tharp Kevin M.; Kang Michael S.; Timblin Greg A.; Dempersmier Jon; Dempsey Garret E.; Zushin Peter-James H.; Benavides Jaime; Choi Catherine; Li Catherine X.; Jha Amit K.; Kajimura Shingo; Healy Kevin E.; Sul Hei Sook; Saijo Kaoru; Kumar Sanjay; Stahl Andreas;

  • 作者单位

    Univ Calif Berkeley Dept Nutr Sci &

    Toxicol Program Metab Biol Berkeley CA 94720 USA;

    Univ Calif Berkeley UC Berkeley UCSF Grad Program Bioengn Berkeley CA 94720 USA;

    Univ Calif Berkeley Dept Mol &

    Cell Biol Berkeley CA 94720 USA;

    Univ Calif Berkeley Dept Nutr Sci &

    Toxicol Program Metab Biol Berkeley CA 94720 USA;

    Univ Calif Berkeley Dept Nutr Sci &

    Toxicol Program Metab Biol Berkeley CA 94720 USA;

    Univ Calif Berkeley Dept Nutr Sci &

    Toxicol Program Metab Biol Berkeley CA 94720 USA;

    Univ Calif Berkeley Dept Nutr Sci &

    Toxicol Program Metab Biol Berkeley CA 94720 USA;

    Univ Calif Berkeley Dept Nutr Sci &

    Toxicol Program Metab Biol Berkeley CA 94720 USA;

    Univ Calif Berkeley Dept Nutr Sci &

    Toxicol Program Metab Biol Berkeley CA 94720 USA;

    Univ Calif Berkeley Dept Bioengn Berkeley CA 94720 USA;

    Univ Calif San Francisco Ctr Diabet San Francisco CA 94143 USA;

    Univ Calif Berkeley Dept Bioengn Berkeley CA 94720 USA;

    Univ Calif Berkeley Dept Nutr Sci &

    Toxicol Program Metab Biol Berkeley CA 94720 USA;

    Univ Calif Berkeley Dept Mol &

    Cell Biol Berkeley CA 94720 USA;

    Univ Calif Berkeley Dept Bioengn Berkeley CA 94720 USA;

    Univ Calif Berkeley Dept Nutr Sci &

    Toxicol Program Metab Biol Berkeley CA 94720 USA;

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  • 正文语种 eng
  • 中图分类 内分泌腺疾病及代谢病;
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