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首页> 外文期刊>Cell metabolism >Drosophila Perpetuates Nutritional Mutualism by Promoting the Fitness of Its Intestinal Symbiont Lactobacillus plantarum
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Drosophila Perpetuates Nutritional Mutualism by Promoting the Fitness of Its Intestinal Symbiont Lactobacillus plantarum

机译：果蝇通过促进其肠道乳杆菌植物乳杆菌的适应性而延续营养相互主义

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摘要

Facultative animal-bacteria symbioses, which are critical determinants of animal fitness, are largely assumed to be mutualistic. However, whether commensal bacteria benefit from the association has not been rigorously assessed. Using a simple and tractable gnotobiotic model-Drosophila mono-associated with one of its dominant commensals, Lactobacillus plantarum-we reveal that in addition to benefiting animal growth, this facultative symbiosis has a positive impact on commensal bacteria fitness. We find that bacteria encounter a strong cost during gut transit, yet larvae-derived maintenance factors override this cost and increase bacterial population fitness, thus perpetuating symbiosis. In addition, we demonstrate that the maintenance of the association is required for achieving maximum animal growth benefits upon chronic undernutrition. Taken together, our study establishes a prototypical case of facultative nutritional mutualism, whereby a farming mechanism perpetuates animal-bacteria symbiosis, which bolsters fitness gains for both partners upon poor nutritional conditions.
机译：兼性动物细菌共生，这是动物健身的关键决定因素，主要被认为是相互主义的。但是，是否尚未严格评估协会的共生细菌是否受益。使用简单且易动的八卵茎模型 - 果蝇单体与其主导的共生之一，乳酸杆菌植物乳菇 - 我们揭示了除了受益于动物的生长外，这种伴侣共生对共生细菌的健身产生了积极的影响。我们发现细菌在肠道过境过程中遭遇强大的成本，但幼虫衍生的维护因素会覆盖这种成本并增加细菌种群健康，从而延长共生。此外，我们证明了在慢性营养性上实现最大的动物生长益处所需的维持。在一起，我们的研究建立了一种兼​​容营养态化的原型案例，由此养殖机制延长了动物细菌共生，在营养状况不佳时，突破了两个伴侣的健身效率。

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  • 来源
    《Cell metabolism》 |2018年第2期|共24页
  • 作者

    Storelli Gilles; Strigini Maura; Grenier Theodore; Bozonnet Loan; Schwarzer Martin; Daniel Catherine; Matos Renata; Leulier Francois;

  • 作者单位

    Univ Claude Bernard Lyon 1 IGFL Ecole Normale Super Lyon CNRS UMR 5242 F-69364 Lyon 07 France;

    Univ Claude Bernard Lyon 1 IGFL Ecole Normale Super Lyon CNRS UMR 5242 F-69364 Lyon 07 France;

    Univ Claude Bernard Lyon 1 IGFL Ecole Normale Super Lyon CNRS UMR 5242 F-69364 Lyon 07 France;

    Univ Claude Bernard Lyon 1 IGFL Ecole Normale Super Lyon CNRS UMR 5242 F-69364 Lyon 07 France;

    Univ Claude Bernard Lyon 1 IGFL Ecole Normale Super Lyon CNRS UMR 5242 F-69364 Lyon 07 France;

    Univ Lille Lact Acid Bacteria &

    Mucosal Immun Team Inst Pasteur Lille Ctr Infect &

    Immun Lille;

    Univ Claude Bernard Lyon 1 IGFL Ecole Normale Super Lyon CNRS UMR 5242 F-69364 Lyon 07 France;

    Univ Claude Bernard Lyon 1 IGFL Ecole Normale Super Lyon CNRS UMR 5242 F-69364 Lyon 07 France;

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  • 正文语种 eng
  • 中图分类 内分泌腺疾病及代谢病;
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