Metformin: An Old Dog with a New Trick?

Claudia C. dos Santos; Bharat Gopal; Subodh Verma

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Metformin: An Old Dog with a New Trick?

机译：二甲双胍：一只新狗，一个新的伎俩？

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Idiopathic pulmonary fibrosis (IPF) remains an important medical challenge, but recent translational data have provided clues implicating deficient AMPK signaling in persistently activated myelofibroblasts within fibrotic foci. A new study inNature Medicinereports that pharmacological activation of AMPK with metformin can reverse established fibrosis by facilitating deactivation and apoptosis of myofibroblasts.

机译：特发性肺纤维化（IPF）仍然是一个重要的医疗挑战，但最近的翻译数据已经提供了在纤维化焦点内持续活化的髓内纤维细胞中缺乏AMPK信号传导的线索。一种新的研究未遂，通过促进肌纤维细胞的失活和凋亡，可以通过促进肌纤维素的凋亡和凋亡来逆转建立的纤维化。

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《Cell metabolism》 |2018年第3期|共3页
作者
Claudia C. dos Santos; Bharat Gopal; Subodh Verma;
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作者单位

Division of Respirology and Interdepartmental Division of Critical Care St. Michael’s Hospital;

Department of Respiratory Medicine Maharaja Agrasen Hospital;

Division of Respirology and Interdepartmental Division of Critical Care St. Michael’s Hospital;

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原文格式 PDF
正文语种 eng
中图分类内分泌腺疾病及代谢病;
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1. Reply from authors re: Robert J. Hamilton. Metformin for castrate-resistant prostate cancer: Learning more about an old dog's new tricks. Eur Urol 2014;66:475-7: The stage is set for metformin [J] . RothermundtC. European urology . 2014,第3期

机译：作者的回复：Robert J. Hamilton。二甲双胍治疗去势抵抗性前列腺癌：了解更多有关老狗的新技巧。 Eur Urol 2014; 66：475-7：为二甲双胍设定阶段
2. Is it the time for metformin to take place in adjuvant treatment of Her-2 positive breast cancer? Teaching new tricks to old dogs. [J] . Yurekli BS, Karaca B, Cetinkalp S Medical hypotheses . 2009,第4期

机译：现在是二甲双胍发生在Her-2阳性乳腺癌的辅助治疗中的时候了吗？向老狗教新的把戏。
3. Metformin: An Old Dog with a New Trick? [J] . Claudia C. dos Santos, Bharat Gopal, Subodh Verma Cell metabolism . 2018,第3期

机译：二甲双胍：一只新狗，一个新的伎俩？
4. Learning New Tricks From Old Dogs: Multi-Source Transfer Learning From Pre-Trained Networks [C] . Joshua Ka-Wing Lee, Prasanna Sattigeri, Gregory W. Wornell Conference on Neural Information Processing Systems . 2020

机译：从旧狗学习新技巧：从预训练的网络中的多源传输学习
5. Old Dogs, New Tricks: Authoritarian Regime Persistence Through Learning [D] . Davis, Nicholas R. 2020

机译：老狗，新技巧：专制政权持久化通过学习
6. Programming T cell Killers for an HIV Cure: Teach the New Dogs New Tricks and Let the Sleeping Dogs Lie [O] . Kellie N. Smith, Robbie B. Mailliard, Charles R. Rinaldo -1

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7. Terrier dogs: showing the best methods of breedings, rearing, feeding, cropping, physicing, cure of diseases, etc. ... also, rats and rat killing ... together with the art of learning dogs tricks. [O] . James, Ed. [from old catalog] 1873

机译：梗犬：展示育种，饲养，喂养，种植，体育，治疗疾病等的最佳方法......还有，老鼠和老鼠的杀戮......以及学习狗技巧的艺术。

Metformin: An Old Dog with a New Trick?

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