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首页> 外文期刊>Cell biology international. >LncRNA MAFG‐AS1 facilitates the migration and invasion of NSCLC cell via sponging miR‐339‐5p from MMP15
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LncRNA MAFG‐AS1 facilitates the migration and invasion of NSCLC cell via sponging miR‐339‐5p from MMP15

机译：LNCRNA MAFG-AS1促进了通过来自MMP15的海绵MIR-339-5P的NSCLC细胞的迁移和侵袭

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摘要

Abstract Non‐small‐cell carcinoma (NSCLC) is the most common cancer along with high mortality rate worldwide. In the present study, our data showed that lncRNA MAF BZIP Transcription Factor G Antisense RNA 1 (MAFG‐AS1) was over‐expressed in NSCLC tissues and cell lines. Overexpression of MAFG‐AS1 promoted the migration, invasion and enhanced epithelial‐mesenchymal transition (EMT) of NSCLC cell. In addition, miR‐339‐5p was predicted to be a target of MAFG‐AS1 and the level of miR‐339‐5p was down‐regulated in NSCLC. Over‐expression of MAFG‐AS1 significantly decreased the level of miR‐339‐5p in NSCLC cell. Moreover, the matrix metalloproteinase 15 (MMP15) was identified to be a target of miR‐339‐5p. The level of MMP15 was negatively regulated by miR‐339‐5p whereas positively controlled by MAFG‐AS1. In addition, up‐regulation of miR‐339‐5p neutralized the promoting impact of MAFG‐AS1 on the migration, invasion and EMT of NSCLC cell. Finally, the xenograft model suggested that MAFG‐AS1 promoted the metastasis of NSCLC cell in vivo. Altogether, we proved that MAFG‐AS1‐miR‐339‐5p‐MMP15 axis might be a promising therapeutic target for the treatment of patients with NSCLC.
机译：摘要非小细胞癌（NSCLC）是最常见的癌症以及全球性高死亡率。在本研究中，我们的数据显示，在NSCLC组织和细胞系中，LNCRNA MAF BZIP转录因子G反义RNA 1（MAFG-AS1）被过度表达。 MAFG-AS1的过度表达促进了NSCLC细胞的迁移，侵袭和增强的上皮 - 间充质转换（EMT）。此外，预计miR-339-5p预计是MAFG-AS1的靶标，MIR-339-5P的水平在NSCLC下调。 MAFG-AS1的过表达显着降低了NSCLC细胞中miR-339-5p的水平。此外，将基质金属蛋白酶15（MMP15）鉴定为miR-339-5p的靶标。 MIR-339-5P对MMP15的水平负调节，而通过MAFG-AS1积极控制。此外，MiR-339-5P的上调中和MAFG-AS1对NSCLC细胞迁移，侵袭和EMT的促进影响。最后，异种移植模型表明MAFG-AS1促进了体内NSCLC细胞的转移。完全，我们证明了MAFG-AS1-MIR-339-5P-MMP15轴可能是治疗NSCLC患者的有希望的治疗靶标。

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  • 来源
    《Cell biology international.》 |2019年第4期|共10页
  • 作者

    Jia You Chao; Wang Jian Yi; Liu Yu Ying; Li Bin; Guo Hui; Zang Ai Min;

  • 作者单位

    Hebei Key Laboratory of Cancer Radiotherapy and ChemotherapyAffiliated Hospital of Hebei;

    Hebei UniversityBaoding Hebei 071000 China;

    Department of OncologyDezhou People's HospitalDezhou Shandong 253014 China;

    Thoracic surgeryDezhou People's HospitalDezhou Shandong 253014 China;

    Pneumology DepartmentDezhou People's HospitalNo. 1751 Xinhu Street Dezhou Shandong 253014 China;

    Hebei Key Laboratory of Cancer Radiotherapy and ChemotherapyAffiliated Hospital of Hebei;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞生物学;
  • 关键词

    EMT; growth; invasion; MAFG‐AS1; NSCLC; MiR‐339‐5p;

    机译：EMT;增长;入侵;MAFG-AS1;NSCLC;MIR-339-5P;

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