Protein phosphatases potentially associated with regulation of microtubules, their spatial structure reconstruction and analysis

Samofalova Dariya O.; Karpov Pavel A.; Raevsky Alexey V.; Blume Yaroslav B.

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Protein phosphatases potentially associated with regulation of microtubules, their spatial structure reconstruction and analysis

机译：蛋白质磷酸酶可能与调节微管，其空间结构重建和分析相关

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Abstract According to the sequence and profile comparison with known catalytic domains, where identified protein phosphatases potentially involved in regulation of microtubule dynamics and structure from Arabidopsis thaliana , Nicotiana tabacum , Medicago sativa , Oryza sativa subsp. japonica, Zea mays , and Triticum aestivum . Selected proteins were related to classical non‐receptor, serine/threonine‐specific and dual protein phosphatases. By application of template structures of human protein phosphatases, it was performed homology modelling of the catalytic domains of 17 plant protein phosphatases. Based on the results of the structural alignment, molecular dynamics, and conservatism in positions of functionally importance, it was confirmed homology of selected plant proteins and known protein phosphatases regulating structure and dynamics of microtubules.

机译：摘要根据与已知催化结构域的序列和轮廓比较，其中鉴定的蛋白质磷酸酶可能涉及调节微管动力学和结构的拟南芥，尼古拉纳塔卡宫，Medicago ativa，Oryza sativa subsp。 japonica，zea mays和triticum aestivum。所选蛋白质与经典的非受体，丝氨酸/苏氨酸特异性和双蛋白磷酸酶有关。通过在人蛋白磷酸酶的模板结构中施加，它进行了17种植物蛋白磷酸酶的催化结构域的同源性建模。基于结构对准，分子动力学和保守主义在功能性重要性的结果的基础上，确认了所选植物蛋白的同源性和已知的蛋白质磷酸酶调节结构和动力学的微管。

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《Cell biology international.》 |2019年第9期|共10页
作者
Samofalova Dariya O.; Karpov Pavel A.; Raevsky Alexey V.; Blume Yaroslav B.;
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作者单位

Institute of Food Biotechnology and GenomicsNatl. Academy of Sci. of UkraineOsipovskogo str. 2a;

Institute of Food Biotechnology and GenomicsNatl. Academy of Sci. of UkraineOsipovskogo str. 2a;

Institute of Food Biotechnology and GenomicsNatl. Academy of Sci. of UkraineOsipovskogo str. 2a;

Institute of Food Biotechnology and GenomicsNatl. Academy of Sci. of UkraineOsipovskogo str. 2a;

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正文语种 eng
中图分类细胞生物学;
关键词
cytoskeleton regulation; microtubules; molecular modeling; PP1; PP2A; PP4;

机译：细胞骨架调节;微管;分子造型;pp1;pp2a;pp4;

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专利

1. Protein phosphatases potentially associated with regulation of microtubules, their spatial structure reconstruction and analysis [J] . Samofalova Dariya O., Karpov Pavel A., Raevsky Alexey V., Cell biology international. . 2019,第9期

机译：蛋白质磷酸酶可能与调节微管，其空间结构重建和分析相关
2. Regulation of phosphorylation of neuronal microtubule-associated proteins MAP1b and MAP2 by protein phosphatase-2A and -2B in rat brain. [J] . Gong CX, Wegiel J, Lidsky T, Brain research . 2000,第2期

机译：大鼠脑中蛋白质磷酸酶2A和-2B调节神经元微管相关蛋白MAP1b和MAP2的磷酸化。
3. Regulation of mitogen-activated protein kinase phosphorylation, microtubule organization, chromatin behavior, and cell cycle progression by protein phosphatases during pig oocyte maturation and fertilization in vitro. [J] . Sun QY, Wu GM, Lai L, Biology of Reproduction: Offical Journal of the Society for the Study of Reproduction . 2002,第3期

机译：在猪卵母细胞成熟和体外受精过程中，通过蛋白磷酸酶调节有丝分裂原激活的蛋白激酶磷酸化，微管组织，染色质行为和细胞周期进程。
4. REGULATION OF PROTEIN PHOSPHORYLATION AT THE POSTSYNAPTIC DENSITY- GLOBAL ANALYSIS TARGETING SPECIFIC KINASE AND PHOSPHATASE ACTIVITIES [C] . Howard Jaffe, Ayse Dosemeci American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2009

机译：在突触后密度 - 全局分析靶向靶向特异性激酶和磷酸酶活性的调节
5. Functional analysis of phosphate starvation-regulated protein phosphatase and a general regulation factor (14-3-3) in plants [D] . Cao, Aiqin 2007

机译：植物磷酸盐饥饿调节蛋白磷酸酶和一般调节因子（14-3-3）的功能分析
6. Regulation of Microtubule Nucleation in Mouse Bone Marrow-Derived Mast Cells by Protein Tyrosine Phosphatase SHP-1 [O] . Anastasiya Klebanovych, Vladimíra Sládková, Tetyana Sulimenko, 2019

机译：酪氨酸磷酸酶SHP-1对小鼠骨髓肥大细胞微管成核的调节。
7. Reconstruction of spatial structure of plant protein phosphatase type 1, 2a and 4 in complexes with microcystin-LR [O] . D. A. Samofalova, P. A. Karpov, O. V. Raievskyi, 1970

机译：植物蛋白磷酸酶1,2A和4中的微囊藻 - LR重建植物蛋白磷酸酶的空间结构

Protein phosphatases potentially associated with regulation of microtubules, their spatial structure reconstruction and analysis

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