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首页> 外文期刊>Cell biology international. >LncRNA TUSC8 inhibits the invasion and migration of cervical cancer cells via miR‐641/PTEN axis
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LncRNA TUSC8 inhibits the invasion and migration of cervical cancer cells via miR‐641/PTEN axis

机译：LNCRNA TUSC8通过MIR-641 / PTEN轴抑制宫颈癌细胞的侵袭和迁移

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摘要

Abstract Cervical cancer (CC) is the fourth leading cause of cancer‐related death in women worldwide. There is an urgent need to find novel targets for the treatment of CC. Recently, microRNA have emerged as critical factors in tumorigenesis. In this study, we aimed to investigate the mechanism of miR‐641 on the migration and invasion of CC cells. In silico analysis revealed putative interaction between miR‐641 and phosphatase and tensin homolog (PTEN) RNA/lncRNA tumor suppressor candidate 8 (TUSC8). Hence we evaluated the expression of TUSC8, miR‐641, and PTEN. We found that the expressions of TUSC8 and PTEN were decreased in CC tissues, whereas miR‐641 expression was increased. Inhibition of miR‐641 suppressed the migration and invasion of Hela cells. In addition, TUSC8 and PTEN were upstream and downstream target molecule of miR‐641, respectively. Overexpression of TUSC8 promoted PTEN expression, and suppressed the invasion and migration of Hela cells, whereas miR‐641 mimic treatment changed the effects. These results demonstrated that overexpression of TUSC8 could inhibit the invasion and migration of CC cells by upregulating PTEN via miR‐641.
机译：摘要宫颈癌（CC）是全球妇女癌症相关死亡的第四个主要原因。迫切需要寻找用于治疗CC的新靶点。最近，MicroRNA已成为肿瘤发生中的关键因素。在这项研究中，我们旨在探讨miR-641对CC细胞迁移和侵袭的机制。在硅分析中，揭示了MiR-641和磷酸酶和磷酸酶和硫素同源物（PTEN）RNA / LNCRNA肿瘤抑制剂8（TUSC8）之间的推定相互作用。因此，我们评估了TUSC8，MIR-641和PTEN的表达。我们发现，在CC组织中，TUSC8和PTEN的表达减少，而MIR-641表达增加。抑制miR-641抑制了HeLa细胞的迁移和侵袭。此外，TUSC8和PTEN分别是miR-641的上游和下游靶分子。 TUSC8的过度表达促进了PTEN表达，并抑制了HELA细胞的侵袭和迁移，而MIR-641模拟处理改变了效果。这些结果表明，TUSC8的过表达可以通过MIR-641上调PTEN来抑制CC细胞的侵袭和迁移。

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  • 来源
    《Cell biology international.》 |2019年第7期|共8页
  • 作者

    Zhu Yanling; Liu Beibei; Zhang Ping; Zhang Jie; Wang Lan;

  • 作者单位

    Department of Gynecology Oncology Xuzhou Cancer HospitalXuzhou Hospital Affiliated to Jiangsu;

    Department of Gynecology Oncology Xuzhou Cancer HospitalXuzhou Hospital Affiliated to Jiangsu;

    Department of Gynecology Oncology Xuzhou Cancer HospitalXuzhou Hospital Affiliated to Jiangsu;

    Department of Gynecology Oncology Xuzhou Cancer HospitalXuzhou Hospital Affiliated to Jiangsu;

    Department of Gynecology Oncology Xuzhou Cancer HospitalXuzhou Hospital Affiliated to Jiangsu;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞生物学;
  • 关键词

    cervical cancer; invasion; migration; miR‐641; PTEN; TUSC8;

    机译：宫颈癌;入侵;迁移;miR-641;PTEN;托斯康;

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