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首页> 外文期刊>Cell biology international. >Polyamines cause elevation of steroid 5alpha-reductase mRNA levels by suppressing mRNA degradation in C6 glioma cells
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Polyamines cause elevation of steroid 5alpha-reductase mRNA levels by suppressing mRNA degradation in C6 glioma cells

机译：多胺通过抑制C6胶质瘤细胞中的mRNA降解导致类固醇5Alpha-还原酶mRNA水平的升高

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Polyamines are widely distributed in living organisms, and considered to play a potential role in various cellular processes. The effects of polyamines on gene expression as well as cell proliferation have been suggested to be closely associated with the physiological and pathological functions. However, it seems necessary to investigate their potential roles in the regulation of cellular metabolism and functions. Previously, glial cells have been suggested to be involved in the protection and preservation of neuronal functions, probably through the production of neurotrophic factors in the brain. On the other hand, neuroactive 5alpah-reduced steroids promote glial cell differentiation, resulting in enhancement of their ability to produce brain-derived neurotrophic factor (BDNF). Based on these findings, polyamines are assumed to stimulate the expression of the gene encoding steroid 5alpah-reductase (5alpah-R), which can induce the production of neuroactive 5alpah-reduced steroids in glial cells. The effects of polyamines on 5alpah-R mRNA levels in C6 glioma cells were examined as a model experiment. In consequence, spermine (SPM) and spermidine (SPD), but not putrescine (PUT), have been shown to elevate 5alpah-R mRNA levels without activating the 5alpah-R promoter. Furthermore, SPM increased 5alpah-R mRNA levels under the conditions in which the mRNA biosynthesis was inhibited. Therefore, it can be speculated that polyamines increase 5alpah-R mRNA levels as a consequence of suppressing the degradation of mRNA.
机译：多胺在生物体中广泛分布，并考虑在各种细胞过程中发挥潜在作用。多胺对基因表达以及细胞增殖的影响与生理和病理功能密切相关。然而，似乎有必要在调节细胞新陈代谢和功能的调节中调查它们的潜在作用。以前，已经提出了胶质细胞参与了神经元功能的保护和保存，可能是通过在大脑中产生神经营养因子的影响。另一方面，神经活性5AlPah降低的类固醇促进胶质细胞分化，导致它们产生脑衍生的神经营养因子（BDNF）的能力。基于这些发现，假设多胺刺激编码类固醇5ALPAH还原酶（5ALPAH-R）的基因的表达，这可以诱导神经胶质细胞中神经活性5ALPAH降低的类固醇的产生。将多胺对C6胶质瘤细胞5AlPah-R mRNA水平的影响被检查为模型实验。结果，已显示精霉素（SPM）和亚精胺（SPD），但不是腐凝素（放置），以升高5alpah-R mRNA水平而不激活5AlPah-R启动子。此外，SPM在抑制mRNA生物合成的条件下增加了5ALPAH-R mRNA水平。因此，可以推测多胺因抑制mRNA的降解而增加5ALPAH-R mRNA水平。

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