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首页> 外文期刊>Cell biology international. >Polyamines cause elevation of steroid 5alpha-reductase mRNA levels by suppressing mRNA degradation in C6 glioma cells
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Polyamines cause elevation of steroid 5alpha-reductase mRNA levels by suppressing mRNA degradation in C6 glioma cells

机译：多胺通过抑制C6胶质瘤细胞中的mRNA降解而导致类固醇5α-还原酶mRNA水平升高

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Polyamines are widely distributed in living organisms, and considered to play a potential role in various cellular processes. The effects of polyamines on gene expression as well as cell proliferation have been suggested to be closely associated with the physiological and pathological functions. However, it seems necessary to investigate their potential roles in the regulation of cellular metabolism and functions. Previously, glial cells have been suggested to be involved in the protection and preservation of neuronal functions, probably through the production of neurotrophic factors in the brain. On the other hand, neuroactive 5alpah-reduced steroids promote glial cell differentiation, resulting in enhancement of their ability to produce brain-derived neurotrophic factor (BDNF). Based on these findings, polyamines are assumed to stimulate the expression of the gene encoding steroid 5alpah-reductase (5alpah-R), which can induce the production of neuroactive 5alpah-reduced steroids in glial cells. The effects of polyamines on 5alpah-R mRNA levels in C6 glioma cells were examined as a model experiment. In consequence, spermine (SPM) and spermidine (SPD), but not putrescine (PUT), have been shown to elevate 5alpah-R mRNA levels without activating the 5alpah-R promoter. Furthermore, SPM increased 5alpah-R mRNA levels under the conditions in which the mRNA biosynthesis was inhibited. Therefore, it can be speculated that polyamines increase 5alpah-R mRNA levels as a consequence of suppressing the degradation of mRNA.
机译：多胺广泛分布于生物体中，并被认为在各种细胞过程中起着潜在的作用。已提出多胺对基因表达以及细胞增殖的影响与生理和病理功能密切相关。但是，似乎有必要研究它们在调节细胞代谢和功能中的潜在作用。以前，已经建议神经胶质细胞可能通过在大脑中产生神经营养因子来参与神经元功能的保护和保存。另一方面，神经活性的5alpah减少的类固醇可促进神经胶质细胞分化，从而增强其产生脑源性神经营养因子（BDNF）的能力。基于这些发现，假定多胺可刺激编码类固醇5alpah-还原酶（5alpah-R）的基因的表达，该基因可诱导神经胶质细胞中5alpah还原的神经活性类固醇的产生。作为模型实验，检查了多胺对C6神经胶质瘤细胞中5alpah-R mRNA水平的影响。因此，已显示精胺（SPM）和亚精胺（SPD），而不是腐胺（PUT），可在不激活5alpah-R启动子的情况下提高5alpah-R mRNA水平。此外，在抑制mRNA生物合成的条件下，SPM增加了5alpah-R mRNA水平。因此，可以推测由于抑制了mRNA的降解，多胺增加了5alpah-R mRNA的水平。

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